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Polymers 2011, 3(1), 100-113; doi:10.3390/polym3010100
Review

Chitosan-Based Hyaluronic Acid Hybrid Polymer Fibers as a Scaffold Biomaterial for Cartilage Tissue Engineering

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Received: 13 October 2010 / Revised: 24 November 2010 / Accepted: 24 December 2010 / Published: 27 December 2010
(This article belongs to the Special Issue Biofunctional Polymers for Medical Applications)
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Abstract

An ideal scaffold material is one that closely mimics the natural environment in the tissue-specific extracellular matrix (ECM). Therefore, we have applied hyaluronic acid (HA), which is a main component of the cartilage ECM, to chitosan as a fundamental material for cartilage regeneration. To mimic the structural environment of cartilage ECM, the fundamental structure of a scaffold should be a three-dimensional (3D) system with adequate mechanical strength. We structurally developed novel polymer chitosan-based HA hybrid fibers as a biomaterial to easily fabricate 3D scaffolds. This review presents the potential of a 3D fabricated scaffold based on these novel hybrid polymer fibers for cartilage tissue engineering.
Keywords: chitosan; hyaluronic acid; hybrid polymer fiber; cartilage tissue engineering; scaffold chitosan; hyaluronic acid; hybrid polymer fiber; cartilage tissue engineering; scaffold
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Iwasaki, N.; Kasahara, Y.; Yamane, S.; Igarashi, T.; Minami, A.; Nisimura, S.-I. Chitosan-Based Hyaluronic Acid Hybrid Polymer Fibers as a Scaffold Biomaterial for Cartilage Tissue Engineering. Polymers 2011, 3, 100-113.

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