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Chitosan-Based Hyaluronic Acid Hybrid Polymer Fibers as a Scaffold Biomaterial for Cartilage Tissue Engineering
Department of Orthopaedic Surgery, School of Medicine, Hokkaido University, Kita 15, Nishi 7, Sapporo 060-8638, Japan
Graduate School of Advanced Life Science, Frontier Research Center for Post-Genomic Science and Technology, Hokkaido University, Kita 10, Nishi 8, Sapporo 060-0810, Japan
* Author to whom correspondence should be addressed.
Received: 13 October 2010; in revised form: 24 November 2010 / Accepted: 24 December 2010 / Published: 27 December 2010
Abstract: An ideal scaffold material is one that closely mimics the natural environment in the tissue-specific extracellular matrix (ECM). Therefore, we have applied hyaluronic acid (HA), which is a main component of the cartilage ECM, to chitosan as a fundamental material for cartilage regeneration. To mimic the structural environment of cartilage ECM, the fundamental structure of a scaffold should be a three-dimensional (3D) system with adequate mechanical strength. We structurally developed novel polymer chitosan-based HA hybrid fibers as a biomaterial to easily fabricate 3D scaffolds. This review presents the potential of a 3D fabricated scaffold based on these novel hybrid polymer fibers for cartilage tissue engineering.
Keywords: chitosan; hyaluronic acid; hybrid polymer fiber; cartilage tissue engineering; scaffold
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Iwasaki, N.; Kasahara, Y.; Yamane, S.; Igarashi, T.; Minami, A.; Nisimura, S.-I. Chitosan-Based Hyaluronic Acid Hybrid Polymer Fibers as a Scaffold Biomaterial for Cartilage Tissue Engineering. Polymers 2011, 3, 100-113.
Iwasaki N, Kasahara Y, Yamane S, Igarashi T, Minami A, Nisimura S-I. Chitosan-Based Hyaluronic Acid Hybrid Polymer Fibers as a Scaffold Biomaterial for Cartilage Tissue Engineering. Polymers. 2011; 3(1):100-113.
Iwasaki, Norimasa; Kasahara, Yasuhiko; Yamane, Shintarou; Igarashi, Tatsuya; Minami, Akio; Nisimura, Shin-ichiro. 2011. "Chitosan-Based Hyaluronic Acid Hybrid Polymer Fibers as a Scaffold Biomaterial for Cartilage Tissue Engineering." Polymers 3, no. 1: 100-113.