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Polymers 2018, 10(9), 949; https://doi.org/10.3390/polym10090949

A Hyaluronic Acid Based Injectable Hydrogel Formed via Photo-Crosslinking Reaction and Thermal-Induced Diels-Alder Reaction for Cartilage Tissue Engineering

1,2
,
1,2,3,* , 1,2,3
,
1,2
,
1,2
and
1,2,3,*
1
Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
2
National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China
3
Key Laboratory of Biomedical Materials and Engineering, Ministry of Education, South China University of Technology, Guangzhou 510006, China
*
Authors to whom correspondence should be addressed.
Received: 10 June 2018 / Revised: 15 August 2018 / Accepted: 18 August 2018 / Published: 27 August 2018
(This article belongs to the Special Issue Soft Materials and Systems)
Full-Text   |   PDF [4891 KB, uploaded 27 August 2018]   |  

Abstract

A hyaluronic acid (HA) based injectable hydrogel with gradually increasing mechanical properties was synthesized via photo-crosslinking reaction and thermal-induced Diels-Alder (DA) reaction. The injectable hydrogel can quickly gelate within 30 s by photo-crosslinking of HA-furan under the catalysis of lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP). This injectable property is beneficial to keep the encapsulated cell activity and convenient for clinical operation. And the mechanical properties can be control from 4.86 to 10.66 kPa by exposure time. Then, the thermal-induced DA click chemistry further occurs between furan groups and maleimide groups which gradually promoted the crosslinking density of the injectable hydrogel. The mechanical properties of the injectable hydrogel can be promoted to 21 kPa. ATDC-5 cells were successfully encapsulated in the injectable hydrogel and showed good activity. All the results suggested that the injectable hydrogel with gradually increasing mechanical properties formed by photo-crosslinking reaction and thermal-induced DA reaction has a good prospect of application in cartilage tissue engineering. View Full-Text
Keywords: injectable hydrogel; photo-crosslinking reaction; DA click chemistry; cartilage tissue engineering injectable hydrogel; photo-crosslinking reaction; DA click chemistry; cartilage tissue engineering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Wang, G.; Cao, X.; Dong, H.; Zeng, L.; Yu, C.; Chen, X. A Hyaluronic Acid Based Injectable Hydrogel Formed via Photo-Crosslinking Reaction and Thermal-Induced Diels-Alder Reaction for Cartilage Tissue Engineering. Polymers 2018, 10, 949.

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