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Polymers 2018, 10(6), 611; https://doi.org/10.3390/polym10060611

Synthetic Glycopolypeptide Micelle for Targeted Drug Delivery to Hepatic Carcinoma

1,2,†
,
1,2,†
,
2
,
2
,
1,* and 2,*
1
Department of Chemistry, Changchun University of Science and Technology, Changchun 130022, China
2
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 13 April 2018 / Revised: 14 May 2018 / Accepted: 22 May 2018 / Published: 4 June 2018
(This article belongs to the Special Issue Smart Polymers)
View Full-Text   |   Download PDF [4241 KB, uploaded 4 June 2018]   |  

Abstract

The targeted delivery of chemotherapy drugs to tumor lesions is a major challenge for the treatment of tumors. Up until now, various polymeric nanoparticles have been explored to improve the targetability of these therapeutic drugs through passive or active targeting processes. In the design and construction of polymer nanoparticles, glycopolypeptide has shown great potential owing to its excellent targeting ability and biocompatibility. In order to enhance the antitumor effect of doxorubicin (DOX), a glycopolypeptide-based micelle (GPM) modified by α-lactose (Lac) was synthesized for targeted treatment of hepatoma. The DOX-loaded GPM (i.e., GPM/DOX) could significantly target human hepatoma (HepG2) cells and further inhibit their proliferation in vitro. Additionally, GPM/DOX exhibited a much higher drug accumulation in tumor tissue and a stronger antitumor effect in vivo than free DOX. The above results revealed that this drug delivery system provides a promising platform for the targeting therapy of hepatic cancer. View Full-Text
Keywords: glycopolypeptide; micelle; targeting chemotherapy; controlled drug release; hepatic carcinoma glycopolypeptide; micelle; targeting chemotherapy; controlled drug release; hepatic carcinoma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, P.; Han, J.; Li, D.; Chen, J.; Wang, W.; Xu, W. Synthetic Glycopolypeptide Micelle for Targeted Drug Delivery to Hepatic Carcinoma. Polymers 2018, 10, 611.

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