Modifying an Active Compound’s Release Kinetic Using a Supercritical Impregnation Process to Incorporate an Active Agent into PLA Electrospun Mats
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Electrospinning of e-PLA and e-PLACIN Nanofibers
2.3. Supercritical Fluid Impregnation of CIN in e-PLA Mats
2.4. Characterization of Active Electrospun PLA Mats
2.4.1. Quantification of CIN in e-PLA Mats
2.4.2. Scanning Electronic Microscopy (SEM) Analysis
2.4.3. Fourier Transform Infrared (FTIR)–Attenuated Total Reflectance (ATR) Spectroscopy
2.4.4. Thermal Properties
2.5. Study of the Release Kinetic of CIN from Active e-PLA Electrospun Mats
2.5.1. Experimental Procedure for CIN Release Rate Quantification in e-PLA Mats
2.6. Statistical Analysis
3. Results and Discussion
3.1. Incorporation of CIN in e-PLA Mats by the scCO2 Impregnation Process
3.2. Morphological Results of e-PLA Mats
3.3. FTIR Analysis Results
3.4. Thermal Characterization of e-PLA Mats
3.5. Study of the Release Kinetic of CIN from e-PLA-CIN and e-PLA/CINimp Mats
Determination of Partition and Diffusion Coefficients of CIN in e-PLA Mats
Supplementary Files
Supplementary File 1Author Contributions
Acknowledgments
Conflicts of Interest
References
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e-Mats | Fiber Diameter (nm) | CIN Content (%) |
---|---|---|
e-PLA | 495 ± 147 | 0 |
e- | 609 ± 218 | 0 |
e-PLA/CINimp | 384 ± 149 | 3.29 ± 0.26 |
e-PLA-CIN | 362 ± 102 | 1.78 ± 0.03 |
Peaks | PLA ext | e-PLA | e- | e-PLA/CINimp | e-PLA-CIN | Assignment |
---|---|---|---|---|---|---|
a | - | - | - | 691 | 691 | CH=CH bending in alkene of CIN |
b | 867 | 867 | 870 | 870 | 867 | PLA amorphous zone |
c | 1040 | 1044 | - | - | - | C-O stretching |
d | 1080 | 1085 | - | - | - | C=O and C-O symmetric stretching |
e | 1180 | 1182 | - | - | - | C-O-C stretching |
f | - | - | - | 1681 | 1679 | aromatic ring and aldehyde group of CIN |
g | 1747 | 1751 | 1752 | 1754 | 1753 | C=O carbonyl stretching |
Materials | Tdeg | Tg (°C) | Tcc (°C) | ΔHcc (J/g) | Tm (°C) | ΔHm (J/g) | Xc’ (%) |
---|---|---|---|---|---|---|---|
PLA ext | 365.1 ± 1.5 b | 63.2 ± 0.7 d | 117.2 ± 0.3 b | 22.3 ± 0.1 b | 155.6 ± 1.7 c | 26.5 ± 0.5 b | 4.6 ± 0.4 b |
e-PLA | 334.0 ± 11.1 a | 53.1 ± 0.2 c | 113.8 ± 0.2 b | 24.7 ± 4.5 b | 153.2 ± 0.3 bc | 25.8 ± 4.2 b | 1.1 ± 0.4 a |
e- | 334.6 ± 8.3 a | 56.7 ± 0.1 c | 122.9 ± 0.5 b | 8.0 ± 1.6 a | 150.9 ± 0.8 b | 9.3 ± 2.3 a | 1.4 ± 0.8 a |
e-PLA/CINimp | 350.8 ± 8.2 ab | 46.5 ± 2.7 b | 103.7 ± 7.2 a | 24.8 ± 0.2 b | 151.2 ± 0.4 b | 27.0 ± 0.4 b | 2.4 ± 0.2 a |
e-PLA-CIN | 349.8 ± 5.9 ab | 38.2 ± 3.9 a | 100.3 ± 4.1 a | 25.3 ± 0.8 b | 147.3 ± 1.5 a | 30.3 ± 0.2 b | 5.4 ± 0.6 b |
e-Mats | KPLA/SS | DCin (m−2 s−1) | RMSE (%) |
---|---|---|---|
e-PLACIN | 470 | 1 × 10−12 | 0.65 |
e-PLA/CINimp | 133 | 6 × 10−14 | 0.71 |
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López de Dicastillo, C.; Villegas, C.; Garrido, L.; Roa, K.; Torres, A.; Galotto, M.J.; Rojas, A.; Romero, J. Modifying an Active Compound’s Release Kinetic Using a Supercritical Impregnation Process to Incorporate an Active Agent into PLA Electrospun Mats. Polymers 2018, 10, 479. https://doi.org/10.3390/polym10050479
López de Dicastillo C, Villegas C, Garrido L, Roa K, Torres A, Galotto MJ, Rojas A, Romero J. Modifying an Active Compound’s Release Kinetic Using a Supercritical Impregnation Process to Incorporate an Active Agent into PLA Electrospun Mats. Polymers. 2018; 10(5):479. https://doi.org/10.3390/polym10050479
Chicago/Turabian StyleLópez de Dicastillo, Carol, Carolina Villegas, Luan Garrido, Karina Roa, Alejandra Torres, María José Galotto, Adrián Rojas, and Julio Romero. 2018. "Modifying an Active Compound’s Release Kinetic Using a Supercritical Impregnation Process to Incorporate an Active Agent into PLA Electrospun Mats" Polymers 10, no. 5: 479. https://doi.org/10.3390/polym10050479