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Polymers 2018, 10(5), 479; https://doi.org/10.3390/polym10050479

Modifying an Active Compound’s Release Kinetic Using a Supercritical Impregnation Process to Incorporate an Active Agent into PLA Electrospun Mats

1
Food Packaging Laboratory (Laben), Department of Science and Food Technology, Faculty of Technology, Center for the Development of Nanoscience and Nanotechnology (CEDENNA), Universidad de Santiago de Chile (USACH), 9170201 Santiago, Chile
2
Laboratory of Membrane Separation Processes (LabProSeM), Department of Chemical Engineering, Engineering Faculty, University of Santiago de Chile (USACH), 9170201 Santiago, Chile
*
Author to whom correspondence should be addressed.
Received: 12 April 2018 / Revised: 23 April 2018 / Accepted: 24 April 2018 / Published: 27 April 2018
(This article belongs to the Special Issue Electrospinning of Nanofibres)
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Abstract

The main objective of this work was to study the release of cinnamaldehyde (CIN) from electrospun poly lactic acid (e-PLA) mats obtained through two techniques: (i) direct incorporation of active compound during the electrospinning process (e-PLA-CIN); and (ii) supercritical carbon dioxide (scCO2) impregnation of CIN within electrospun PLA mats (e-PLA/CINimp). The development and characterization of both of these active electrospun mats were investigated with the main purpose of modifying the release kinetic of this active compound. Morphological, structural, and thermal properties of these materials were also studied, and control mats e-PLA and e- PLA CO 2 were developed in order to understand the effect of electrospinning and scCO2 impregnation, respectively, on PLA properties. Both strategies of incorporation of this active compound into PLA matrix resulted in different morphologies that influenced chemical and physical properties of these composites and in different release kinetics of CIN. The electrospinning and scCO2 impregnation processes and the presence of CIN altered PLA thermal and structural properties when compared to an extruded PLA material. The incorporation of CIN through scCO2 impregnation resulted in higher release rate and lower diffusion coefficients when compared to active electrospun mats with CIN incorporated during the electrospinning process. View Full-Text
Keywords: electrospinning; poly (acid lactic), cinnamaldehyde; supercritical impregnation; release kinetic electrospinning; poly (acid lactic), cinnamaldehyde; supercritical impregnation; release kinetic
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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López de Dicastillo, C.; Villegas, C.; Garrido, L.; Roa, K.; Torres, A.; Galotto, M.J.; Rojas, A.; Romero, J. Modifying an Active Compound’s Release Kinetic Using a Supercritical Impregnation Process to Incorporate an Active Agent into PLA Electrospun Mats. Polymers 2018, 10, 479.

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