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Polymers 2018, 10(3), 243; https://doi.org/10.3390/polym10030243

Thiolated Hyaluronic Acid as Versatile Mucoadhesive Polymer: From the Chemistry Behind to Product Developments—What Are the Capabilities?

1
Thiomatrix Forschungs-und Beratungs GmbH, Trientlgasse 65, 6020 Innsbruck, Austria
2
Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria
*
Author to whom correspondence should be addressed.
Received: 12 January 2018 / Revised: 7 February 2018 / Accepted: 24 February 2018 / Published: 28 February 2018
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Abstract

Within the last decade, intensive research work has been conducted on thiolated hyaluronic acids (HA-SH). By attaching sulfhydryl ligands onto naturally occurring hyaluronic acid various types of HA-SH can be designed. Due the ability of disulfide bond formation within the polymer itself as well as with biological materials, certain properties such as mucoadhesive, gelling, enzyme inhibitory, permeation enhancing and release controlling properties are improved. Besides the application in the field of drug delivery, HA-SH has been investigated as auxiliary material for wound healing. Within this review, the characteristics of novel drug delivery systems based on HA-SH are summarized and the versatility of this polymer for further applications is described by introducing numerous relevant studies in this field. View Full-Text
Keywords: thiolated hyaluronic acid; hydrogel; mucoadhesive; biocompatibility; controlled release; drug delivery; wound healing thiolated hyaluronic acid; hydrogel; mucoadhesive; biocompatibility; controlled release; drug delivery; wound healing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Griesser, J.; Hetényi, G.; Bernkop-Schnürch, A. Thiolated Hyaluronic Acid as Versatile Mucoadhesive Polymer: From the Chemistry Behind to Product Developments—What Are the Capabilities? Polymers 2018, 10, 243.

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