Next Article in Journal
Synthesis, Characterization, and Applications of Magnetic Nanoparticles Featuring Polyzwitterionic Coatings
Next Article in Special Issue
Site-Specific DBCO Modification of DEC205 Antibody for Polymer Conjugation
Previous Article in Journal
One-Pot Synthesis of Waterborne Polymeric Dispersions Stabilized with Alkali-Soluble Resins
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Polymers 2018, 10(1), 89; https://doi.org/10.3390/polym10010089

Poly(carbonate urethane)-Based Thermogels with Enhanced Drug Release Efficacy for Chemotherapeutic Applications

1
Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, #08-03 Innovis, Singapore 138634, Singapore
2
Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117575, Singapore
3
Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China
4
Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751, Singapore
These authors have made equal contributions to this work.
*
Authors to whom correspondence should be addressed.
Received: 1 December 2017 / Revised: 9 January 2018 / Accepted: 15 January 2018 / Published: 18 January 2018
(This article belongs to the Special Issue Polymers for Therapy and Diagnostics)
View Full-Text   |   Download PDF [5122 KB, uploaded 18 January 2018]   |  

Abstract

In this study, we report the synthesis and characterisation of a thermogelling poly(carbonate urethane) system comprising poly(ethylene glycol) (PEG), poly(propylene glycol) (PPG) and poly(polytetrahydrofuran carbonate) (PTHF carbonate). The incorporation of PTHF carbonate allowed for the control of the lower critical solution temperature (LCST) and decreased critical gelation concentration (CGC) of the thermogels significantly. In addition, the as-prepared thermogels displayed low toxicity against HepG2, L02 and HEK293T cells. Drug release studies were carried out using doxorubicin (Dox). Studies conducted using nude mice models with hepatocellular carcinoma revealed that the Dox-loaded poly(PEG/PPG/PTHF carbonate urethane) thermogels showed excellent in vivo anti-tumour performance and effectively inhibited tumour growth in the tested model. View Full-Text
Keywords: in-situ hydrogel; thermo-responsive polymers; drug release; cancer therapy in-situ hydrogel; thermo-responsive polymers; drug release; cancer therapy
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Chan, B.Q.Y.; Cheng, H.; Liow, S.S.; Dou, Q.; Wu, Y.-L.; Loh, X.J.; Li, Z. Poly(carbonate urethane)-Based Thermogels with Enhanced Drug Release Efficacy for Chemotherapeutic Applications. Polymers 2018, 10, 89.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top