Next Article in Journal
Antimicrobial Carvacrol-Containing Polypropylene Films: Composition, Structure and Function
Next Article in Special Issue
Aggregation of Cationic Amphiphilic Block and Random Copoly(vinyl ether)s with Antimicrobial Activity
Previous Article in Journal
Mechanical Properties and Wear Resistance of Sulfonated Graphene/Waterborne Polyurethane Composites Prepared by In Situ Method
Previous Article in Special Issue
Theory of the Flower Micelle Formation of Amphiphilic Random and Periodic Copolymers in Solution
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Polymers 2018, 10(1), 76; https://doi.org/10.3390/polym10010076

A Comparative Study on Micellar and Solubilizing Behavior of Three EO-PO Based Star Block Copolymers Varying in Hydrophobicity and Their Application for the In Vitro Release of Anticancer Drugs

1
Department of Chemistry, Veer Narmad South Gujarat University, Surat 395007, India
2
Department of Zoology, PT Sarvajanik College of Science, Surat 395001, India
*
Author to whom correspondence should be addressed.
Received: 16 December 2017 / Revised: 1 January 2018 / Accepted: 13 January 2018 / Published: 15 January 2018
(This article belongs to the Special Issue Polymer Micelles)
Full-Text   |   PDF [8877 KB, uploaded 15 January 2018]   |  

Abstract

The temperature and pH dependent self-assembly of three star shaped ethylene oxide-propylene oxide (EO-PO) block copolymers (Tetronics® 304, 904 and 908) with widely different hydrophobicity was examined in aqueous solutions. Physico-chemical methods viz. viscosity, cloud point, solubilization along with thermal, scattering and spectral techniques shows strongly temperature and salt dependent solution behavior. T304 possessing low molecular weight did not form micelles; moderately hydrophilic T904 remained as micelles at ambient temperature and showed micellar growth while very hydrophilic T908 formed micelles at elevated temperatures. The surface activity/micellization/solubilization power was favored in the presence of salt. The copolymers turn more hydrophilic in acidic pH due to protonation of central ethylene diamine moiety that hinders micelle formation. The solubilization of a model insoluble azo dye 1-(o-Tolylazo)-2-naphthol (Orange OT) and hydrophobic drugs (quercetin and curcumin) for copolymer solutions in aqueous and salt solutions are also reported. Among the three copolymers, T904 showed maximum solubility of dye and drugs, hence the in vitro release of drugs from T904 micelles was estimated and the effect on cytotoxicity of loading the drugs in T904 micelles was compared with the cytotoxicity of free drugs on the CHO-K1 cells. The results from the present work provide a better insight in selection of Tetronics® for their application in different therapeutic applications. View Full-Text
Keywords: Tetronics; micelles; in vitro release; anticancer drugs; solubilization; drug delivery Tetronics; micelles; in vitro release; anticancer drugs; solubilization; drug delivery
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Vyas, B.; Pillai, S.A.; Bahadur, A.; Bahadur, P. A Comparative Study on Micellar and Solubilizing Behavior of Three EO-PO Based Star Block Copolymers Varying in Hydrophobicity and Their Application for the In Vitro Release of Anticancer Drugs. Polymers 2018, 10, 76.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top