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Polymers 2018, 10(1), 10; doi:10.3390/polym10010010

Magnetic Nanoparticles Coated with a Thermosensitive Polymer with Hyperthermia Properties

Department of Applied Physics, University of Granada, Av. Fuentenueva s/n, 18071 Granada, Spain
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences; Monash University, Parkville, Victoria 3052, Australia
Author to whom correspondence should be addressed.
Received: 9 November 2017 / Revised: 12 December 2017 / Accepted: 19 December 2017 / Published: 22 December 2017
(This article belongs to the Special Issue Selected Papers from "ECIS 2017")
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Magnetic nanoparticles (MNPs) have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by the enhanced permeability and retention effect. Their incorporation into biopolymer coatings enables the preparation of magnetic field-responsive, biocompatible nanoparticles that are well dispersed in aqueous media. Here we describe a synthetic route to prepare functionalized, stable magnetite nanoparticles (MNPs) coated with a temperature-responsive polymer, by means of the hydrothermal method combined with an oil/water (o/w) emulsion process. The effects of both pH and temperature on the electrophoretic mobility and surface charge of these MNPs are investigated. The magnetite/polymer composition of these systems is detected by Fourier Transform Infrared Spectroscopy (FTIR) and quantified by thermogravimetric analysis. The therapeutic possibilities of the designed nanostructures as effective heating agents for magnetic hyperthermia are demonstrated, and specific absorption rates as high as 150 W/g, with 20 mT magnetic field and 205 kHz frequency, are obtained. This magnetic heating response could provide a promising nanoparticle system for combined diagnostics and cancer therapy. View Full-Text
Keywords: hyperthermia; magnetite nanostructures; polymer coating; temperature-responsive polymer hyperthermia; magnetite nanostructures; polymer coating; temperature-responsive polymer

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Reyes-Ortega, F.; Delgado, Á.V.; Schneider, E.K.; Checa Fernández, B.L.; Iglesias, G.R. Magnetic Nanoparticles Coated with a Thermosensitive Polymer with Hyperthermia Properties. Polymers 2018, 10, 10.

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