Crystals 2014, 4(2), 123-140; doi:10.3390/cryst4020123
Article

From Evaporative to Cooling Crystallisation: An Initial Co-Crystallisation Study of Cytosine and Its Fluorinated Derivative with 4-chloro-3,5-dinitrobenzoic Acid

1,2email, 1email, 1email and 1,2,* email
Received: 20 December 2013; in revised form: 21 May 2014 / Accepted: 29 May 2014 / Published: 11 June 2014
(This article belongs to the Special Issue Crystallisation Control)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Two new multi-component molecular complexes of cytosine and 5-fluorocytosine with 4-chloro-3,5-dinitrobenzoic acid are presented. Materials synthesis was achieved initially by evaporative crystallisation and the crystal structures determined. The process was then successfully transferred into a controlled small scale cooling crystallisation environment, with bulk samples shown to be representative of the multi-component product phase, by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) methods. Turbidity measurements are shown to be a valuable process analytical technology probe for characterising the initial stages of molecular complex formation in solution. The significance of these findings for scale-up of crystallisation of multi-component molecular materials and for future transfer into continuous cooling crystallisation is discussed.
Keywords: molecular complexes; multi-component crystallisation; continuous manufacturing and crystallisation; cooling crystallisation; process analytical technologies; turbidity measurements
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MDPI and ACS Style

Wittering, K.; King, J.; Thomas, L.H.; Wilson, C.C. From Evaporative to Cooling Crystallisation: An Initial Co-Crystallisation Study of Cytosine and Its Fluorinated Derivative with 4-chloro-3,5-dinitrobenzoic Acid. Crystals 2014, 4, 123-140.

AMA Style

Wittering K, King J, Thomas LH, Wilson CC. From Evaporative to Cooling Crystallisation: An Initial Co-Crystallisation Study of Cytosine and Its Fluorinated Derivative with 4-chloro-3,5-dinitrobenzoic Acid. Crystals. 2014; 4(2):123-140.

Chicago/Turabian Style

Wittering, Kate; King, Josh; Thomas, Lynne H.; Wilson, Chick C. 2014. "From Evaporative to Cooling Crystallisation: An Initial Co-Crystallisation Study of Cytosine and Its Fluorinated Derivative with 4-chloro-3,5-dinitrobenzoic Acid." Crystals 4, no. 2: 123-140.

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