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Catalysts 2017, 7(10), 288; doi:10.3390/catal7100288

Polycyclic Ketone Monooxygenase (PockeMO): A Robust Biocatalyst for the Synthesis of Optically Active Sulfoxides

Departamento de Química Orgánica, Universidad de Sevilla, c/Profesor García González 1, 41012 Sevilla, Spain
Molecular Enzymology Group, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
Author to whom correspondence should be addressed.
Received: 12 August 2017 / Revised: 16 September 2017 / Accepted: 21 September 2017 / Published: 27 September 2017
(This article belongs to the Special Issue Biocatalysis and Biotransformations)
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A recently discovered, moderately thermostable Baeyer-Villiger monooxygenase, polycyclic ketone monooxygenase (PockeMO), from Thermothelomyces thermophila has been employed as a biocatalyst in a set of asymmetric sulfoxidations. The enzyme was able to catalyze the oxidation of various alkyl aryl sulfides with good selectivities and moderate to high activities. The biocatalytic performance was able to be further increased by optimizing some reaction parameters, such as the addition of 10% v v−1 of water miscible solvents or toluene, or by performing the conversion at a relatively high temperature (45 °C). PockeMO was found to display an optimum activity at sulfide concentrations of 50 mM, while it can also function at 200 mM. Taken together, the data show that PockeMO can be used as robust biocatalyst for the synthesis of optically active sulfoxides. View Full-Text
Keywords: biocatalysis; Baeyer-Villiger monooxygenases; chiral sulfoxides; selective oxidations biocatalysis; Baeyer-Villiger monooxygenases; chiral sulfoxides; selective oxidations

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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de Gonzalo, G.; Fürst, M.J.L.J.; Fraaije, M.W. Polycyclic Ketone Monooxygenase (PockeMO): A Robust Biocatalyst for the Synthesis of Optically Active Sulfoxides. Catalysts 2017, 7, 288.

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