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Cancers 2017, 9(9), 124; doi:10.3390/cancers9090124

MicroRNAs as Biomarkers in Colorectal Cancer

Department of Surgery, Kyushu University Beppu Hospital, 4546 Tsurumihara, Beppu 874-0838, Japan
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Academic Editors: Takahiro Ochiya and Ryou-u Takahashi
Received: 29 June 2017 / Revised: 1 September 2017 / Accepted: 10 September 2017 / Published: 13 September 2017
View Full-Text   |   Download PDF [235 KB, uploaded 13 September 2017]

Abstract

MicroRNAs (miRs) are small RNAs that repress mRNA translation, resulting in the degradation of mRNAs and regulation of the expression levels of various genes. Recent studies have shown that aberrant miR expression has a functional role in the initiation and progression of various malignancies, including colorectal cancer (CRC), which is one of the leading causes of cancer-related death worldwide. miRs have also been shown to have applications as diagnostic, prognostic, and predictive biomarkers because of their high tissue specificity, stability, and altered expression in tumor development. In this report, we examined the role of miRs as biomarkers in CRC through a review of meta-analyses and large-scale analyses having strong statistical confidence in the study outcomes. We also discuss current issues in the clinical application of these miRs. View Full-Text
Keywords: microRNA; biomarker; colorectal cancer microRNA; biomarker; colorectal cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Masuda, T.; Hayashi, N.; Kuroda, Y.; Ito, S.; Eguchi, H.; Mimori, K. MicroRNAs as Biomarkers in Colorectal Cancer. Cancers 2017, 9, 124.

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