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Cancers 2017, 9(9), 123; https://doi.org/10.3390/cancers9090123

Anaplastic Lymphoma Kinase in Cutaneous Malignancies

1
Harvard Medical School, Boston, MA 02115, USA
2
Department of Dermatology, Brigham and Women’s Hospital, Boston, MA 02115, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Raymond Lai
Received: 8 August 2017 / Revised: 5 September 2017 / Accepted: 10 September 2017 / Published: 12 September 2017
(This article belongs to the Special Issue Targeting ALK in Cancer)
View Full-Text   |   Download PDF [243 KB, uploaded 12 September 2017]

Abstract

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that has been implicated in the pathogenesis of a variety of neoplasms. As suggested by its name, ALK was first described as part of a translocation product in cases of anaplastic large-cell lymphoma, with other genetic and cytogenetic ALK mutations subsequently coming to attention in the development of many other hematologic and solid organ malignancies. ALK has now been shown to play a role in the pathogenesis of several cutaneous malignancies, including secondary cutaneous systemic anaplastic large-cell lymphoma (ALCL) and primary cutaneous ALCL, melanoma, spitzoid tumors, epithelioid fibrous histiocytoma, Merkel cell carcinoma, and basal cell carcinoma. The characterization of ALK-positivity in these cutaneous malignancies presents exciting opportunities for utilizing ALK-targeted inhibitors in the treatment of these diseases. View Full-Text
Keywords: anaplastic lymphoma kinase; cutaneous malignancy; anaplastic large cell lymphoma; crizotinib anaplastic lymphoma kinase; cutaneous malignancy; anaplastic large cell lymphoma; crizotinib
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Cao, S.; Nambudiri, V.E. Anaplastic Lymphoma Kinase in Cutaneous Malignancies. Cancers 2017, 9, 123.

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