Epithelial-to-Pericyte Transition in Cancer
AbstractDuring epithelial-to-mesenchymal transition (EMT), cells lose epithelial characteristics and acquire mesenchymal properties. These two processes are genetically separable and governed by distinct transcriptional programs, rendering the EMT outputs highly heterogeneous. Our recent study shows that the mesenchymal products generated by EMT often express multiple pericyte markers, associate with and stabilize blood vessels to fuel tumor growth, thus phenotypically and functionally resembling pericytes. Therefore, some EMT events represent epithelial-to-pericyte transition (EPT). The serum response factor (SRF) plays key roles in both EMT and differentiation of pericytes, and may inherently confer the pericyte attributes on EMT cancer cells. By impacting their intratumoral location and cell surface receptor expression, EPT may enable cancer cells to receive and respond to angiocrine factors produced by the vascular niche, and develop therapy resistance. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Lu, J.; Shenoy, A.K. Epithelial-to-Pericyte Transition in Cancer. Cancers 2017, 9, 77.
Lu J, Shenoy AK. Epithelial-to-Pericyte Transition in Cancer. Cancers. 2017; 9(7):77.Chicago/Turabian Style
Lu, Jianrong; Shenoy, Anitha K. 2017. "Epithelial-to-Pericyte Transition in Cancer." Cancers 9, no. 7: 77.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.