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Cancers 2017, 9(7), 72; doi:10.3390/cancers9070072

Epigenetic Regulation of the Epithelial to Mesenchymal Transition in Lung Cancer

1
Laboratoire Ecologie et Biologie des Interactions, Equipe SEVE, Université de Poitiers, UMR CNRS 7267, F-86073 Poitiers, France
2
Division of Hematology-Oncology, Medical University of South Carolina, 39 Sabin St., MSC 635, Charleston, SC 29425, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Samuel C. Mok
Received: 29 May 2017 / Revised: 17 June 2017 / Accepted: 17 June 2017 / Published: 24 June 2017
(This article belongs to the Special Issue The Epithelial-to-Mesenchymal Transition (EMT) in Cancer)
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Abstract

Lung cancer is the leading cause of cancer deaths worldwide. It is an aggressive and devastating cancer because of metastasis triggered by enhanced migration and invasion, and resistance to cytotoxic chemotherapy. The epithelial to mesenchymal transition (EMT) is a fundamental developmental process that is reactivated in wound healing and a variety of diseases including cancer where it promotes migration/invasion and metastasis, resistance to treatment, and generation and maintenance of cancer stem cells. The induction of EMT is associated with reprogramming of the epigenome. This review focuses on major mechanisms of epigenetic regulation mainly in lung cancer with recent data on EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit ), the catalytic subunit of the PRC2 (Polycomb Group PcG), that behaves as an oncogene in lung cancer associated with gene repression, non-coding RNAs and the epitranscriptome. View Full-Text
Keywords: chromatin modifications; EMT; Epigenetics; Epitranscriptomics; EZH2; non-coding RNAs; NSCLC; SCLC chromatin modifications; EMT; Epigenetics; Epitranscriptomics; EZH2; non-coding RNAs; NSCLC; SCLC
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Roche, J.; Gemmill, R.M.; Drabkin, H.A. Epigenetic Regulation of the Epithelial to Mesenchymal Transition in Lung Cancer. Cancers 2017, 9, 72.

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