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Cancers 2017, 9(2), 12; doi:10.3390/cancers9020012

Interstitial Photodynamic Therapy—A Focused Review

1
Photodynamic Therapy Center, Department of Cell Stress Biology, Roswell Park Cancer Institute (RPCI), Elm & Carlton Streets, Buffalo, NY 14263, USA
2
Simphotek, Inc., 211 Warren St, Newark, NJ 07103, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Michael R. Hamblin
Received: 1 December 2016 / Revised: 13 January 2017 / Accepted: 20 January 2017 / Published: 24 January 2017
(This article belongs to the Special Issue Photodynamic Cancer Therapy)
View Full-Text   |   Download PDF [671 KB, uploaded 24 January 2017]   |  

Abstract

Multiple clinical studies have shown that interstitial photodynamic therapy (I-PDT) is a promising modality in the treatment of locally-advanced cancerous tumors. However, the utilization of I-PDT has been limited to several centers. The objective of this focused review is to highlight the different approaches employed to administer I-PDT with photosensitizers that are either approved or in clinical studies for the treatment of prostate cancer, pancreatic cancer, head and neck cancer, and brain cancer. Our review suggests that I-PDT is a promising treatment in patients with large-volume or thick tumors. Image-based treatment planning and real-time dosimetry are required to optimize and further advance the utilization of I-PDT. In addition, pre- and post-imaging using computed tomography (CT) with contrast may be utilized to assess the response. View Full-Text
Keywords: interstitial photodynamic therapy; prostate; head and neck; pancreatic; brain; treatment planning interstitial photodynamic therapy; prostate; head and neck; pancreatic; brain; treatment planning
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Shafirstein, G.; Bellnier, D.; Oakley, E.; Hamilton, S.; Potasek, M.; Beeson, K.; Parilov, E. Interstitial Photodynamic Therapy—A Focused Review. Cancers 2017, 9, 12.

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