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Cancers 2017, 9(11), 152; doi:10.3390/cancers9110152

Evolving Significance and Future Relevance of Anti-Angiogenic Activity of mTOR Inhibitors in Cancer Therapy

Department of Visceral Surgery, Lausanne University Hospital, Pavillon 4, avenue de Beaumont, 1011 Lausanne, Switzerland
Author to whom correspondence should be addressed.
Academic Editors: Andrew R. Tee and James Murray
Received: 4 September 2017 / Revised: 23 October 2017 / Accepted: 27 October 2017 / Published: 1 November 2017
(This article belongs to the Special Issue mTOR Pathway in Cancer)
View Full-Text   |   Download PDF [1089 KB, uploaded 1 November 2017]   |  


mTOR inhibitors have demonstrated remarkable anti-tumor activity in experimental models, mainly by reducing cancer cell growth and tumor angiogenesis. Their use in cancer patients as monotherapy has, however, generated only limited benefits, increasing median overall survival by only a few months. Likewise, in other targeted therapies, cancer cells develop resistance mechanisms to overcome mTOR inhibition. Hence, novel therapeutic strategies have to be designed to increase the efficacy of mTOR inhibitors in cancer. In this review, we discuss the present and future relevance of mTOR inhibitors in cancer therapy by focusing on their effects on tumor angiogenesis. View Full-Text
Keywords: mTOR; tumor angiogenesis; rapalogs; cancer; endothelial cell mTOR; tumor angiogenesis; rapalogs; cancer; endothelial cell

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Faes, S.; Santoro, T.; Demartines, N.; Dormond, O. Evolving Significance and Future Relevance of Anti-Angiogenic Activity of mTOR Inhibitors in Cancer Therapy. Cancers 2017, 9, 152.

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