Next Article in Journal
Care at the Very End-of-Life: Dying Cancer Patients and Their Chosen Family’s Needs
Next Article in Special Issue
A Tale of Two Signals: AR and WNT in Development and Tumorigenesis of Prostate and Mammary Gland
Previous Article in Journal / Special Issue
Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview
Cancers 2017, 9(1), 10; doi:10.3390/cancers9010010

Stromal Androgen Receptor in Prostate Cancer Development and Progression

1
The Basil Hetzel Institute for Translational Health Research, The University of Adelaide, Adelaide 5011, Australia
2
Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
3
Department of Radiation Oncology, Canberra Teaching Hospital, Canberra 2605, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Emmanuel S. Antonarakis
Received: 30 November 2016 / Revised: 13 January 2017 / Accepted: 16 January 2017 / Published: 22 January 2017
(This article belongs to the Special Issue AR Signaling in Human Malignancies: Prostate Cancer and Beyond)
View Full-Text   |   Download PDF [2226 KB, uploaded 22 January 2017]   |  

Abstract

Prostate cancer development and progression is the result of complex interactions between epithelia cells and fibroblasts/myofibroblasts, in a series of dynamic process amenable to regulation by hormones. Whilst androgen action through the androgen receptor (AR) is a well-established component of prostate cancer biology, it has been becoming increasingly apparent that changes in AR signalling in the surrounding stroma can dramatically influence tumour cell behavior. This is reflected in the consistent finding of a strong association between stromal AR expression and patient outcomes. In this review, we explore the relationship between AR signalling in fibroblasts/myofibroblasts and prostate cancer cells in the primary site, and detail the known functions, actions, and mechanisms of fibroblast AR signaling. We conclude with an evidence-based summary of how androgen action in stroma dramatically influences disease progression. View Full-Text
Keywords: prostate cancer; stroma; fibroblasts; androgen; androgen receptor prostate cancer; stroma; fibroblasts; androgen; androgen receptor
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Leach, D.A.; Buchanan, G. Stromal Androgen Receptor in Prostate Cancer Development and Progression. Cancers 2017, 9, 10.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top