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Cancers 2016, 8(8), 71; doi:10.3390/cancers8080071

CD8 T Cell–Independent Antitumor Response and Its Potential for Treatment of Malignant Gliomas

1
Department of Urology, University of Minnesota, Minneapolis, MN 55455, USA
2
Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
3
Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Vita Golubovskaya
Received: 25 April 2016 / Revised: 30 June 2016 / Accepted: 19 July 2016 / Published: 27 July 2016
(This article belongs to the Special Issue Cancer Immunotherapies)
View Full-Text   |   Download PDF [549 KB, uploaded 27 July 2016]   |  

Abstract

Malignant brain tumors continue to represent a devastating diagnosis with no real chance for cure. Despite an increasing list of potential salvage therapies, standard-of-care for these patients has not changed in over a decade. Immunotherapy has been seen as an exciting option, with the potential to offer specific and long lasting tumor clearance. The “gold standard” in immunotherapy has been the development of a tumor-specific CD8 T cell response to potentiate tumor clearance and immunological memory. While many advances have been made in the field of immunotherapy, few therapies have seen true success. Many of the same principles used to develop immunotherapy in tumors of the peripheral organs have been applied to brain tumor immunotherapy. The immune-specialized nature of the brain should call into question whether this approach is appropriate. Recent results from our own experiments require a rethinking of current dogma. Perhaps a CD8 T cell response is not sufficient for an organ as immunologically unique as the brain. Examination of previously elucidated principles of the brain’s immune-specialized status and known immunological preferences should generate discussion and experimentation to address the failure of current therapies. View Full-Text
Keywords: brain tumors; immunotherapy; T cells brain tumors; immunotherapy; T cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Murphy, K.A.; Griffith, T.S. CD8 T Cell–Independent Antitumor Response and Its Potential for Treatment of Malignant Gliomas. Cancers 2016, 8, 71.

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