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Cancers 2015, 7(4), 2386-2396; doi:10.3390/cancers7040898

Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks

1
Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA
2
Department of Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA
3
Department of Neurosurgery, Penn State University College of Medicine, Hershey, PA 17033, USA
4
Department of Public Health Sciences, Penn State University College of Medicine, 500 University Drive, CH69, Hershey, PA 17033, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Alba Minelli
Received: 31 August 2015 / Revised: 25 October 2015 / Accepted: 2 December 2015 / Published: 9 December 2015
View Full-Text   |   Download PDF [235 KB, uploaded 9 December 2015]

Abstract

Background: Polymorphisms in the hemochromatosis (HFE) gene are associated with excessive iron absorption from the diet, and pro-oxidant effects of iron accumulation are thought to be a risk factor for several types of cancer. Methods: The C282Y (rs1800562) and H63D (rs1799945) polymorphisms were genotyped in 301 oral cancer cases and 437 controls and analyzed in relation to oral cancer risk, and serum iron biomarker levels from a subset of 130 subjects. Results: Individuals with the C282Y allele had lower total iron binding capacity (TIBC) (321.2 ± 37.2 µg/dL vs. 397.7 ± 89.0 µg/dL, p = 0.007) and higher percent transferrin saturation (22.0 ± 8.7 vs. 35.6 ± 22.9, p = 0.023) than wild type individuals. Iron and ferritin levels approached significantly higher levels for the C282Y allele (p = 0.0632 and p = 0.0588, respectively). Conclusions: Iron biomarker levels were elevated by the C282Y allele, but neither (rs1800562) nor (rs1799945) was associated with oral cancer risk in blacks and whites. View Full-Text
Keywords: HFE; SNP; iron homeostasis; oral cancer; White; Black; genotyping HFE; SNP; iron homeostasis; oral cancer; White; Black; genotyping
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Jones, N.R.; Ashmore, J.H.; Lee, S.Y.; Richie, J.P.; Lazarus, P.; Muscat, J.E. Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks. Cancers 2015, 7, 2386-2396.

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