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Cancers 2015, 7(4), 2262-2276; doi:10.3390/cancers7040889

Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy

1
Molecular Biology of Selenium Section, Mouse Cancer Genetics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
2
Department of Biological Sciences, Towson University, Towson, MD 21252, USA
3
School of Biological Sciences, Seoul National University, Seoul 151-742, Korea
4
Department of Medicine, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA 02115,USA
Present Address: Laboratory of Applied Molecular Microbiology, Department of Biotechnology, College of Life Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga 525-0058, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Alba Minelli
Received: 4 August 2015 / Revised: 14 October 2015 / Accepted: 29 October 2015 / Published: 10 November 2015
View Full-Text   |   Download PDF [993 KB, uploaded 10 November 2015]   |  

Abstract

A common characteristic of many cancer cells is that they suffer from oxidative stress. They, therefore, require effective redox regulatory systems to combat the higher levels of reactive oxygen species that accompany accelerated growth compared to the normal cells of origin. An elevated dependence on these systems in cancers suggests that targeting these systems may provide an avenue for retarding the malignancy process. Herein, we examined the redox regulatory systems in human liver and lung cancers by comparing human lung adenocarcinoma and liver carcinoma to their respective surrounding normal tissues. Significant differences were found in the two major redox systems, the thioredoxin and glutathione systems. Thioredoxin reductase 1 levels were elevated in both malignancies, but thioredoxin was highly upregulated in lung tumor and only slightly upregulated in liver tumor, while peroxiredoxin 1 was highly elevated in lung tumor, but downregulated in liver tumor. There were also major differences within the glutathione system between the malignancies and their normal tissues. The data suggest a greater dependence of liver on either the thioredoxin or glutathione system to drive the malignancy, while lung cancer appeared to depend primarily on the thioredoxin system. View Full-Text
Keywords: antioxidant systems; thioredoxin reductase 1; thioredoxin 1; glutathione; glutathione peroxidase antioxidant systems; thioredoxin reductase 1; thioredoxin 1; glutathione; glutathione peroxidase
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tobe, R.; Carlson, B.A.; Tsuji, P.A.; Lee, B.J.; Gladyshev, V.N.; Hatfield, D.L. Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy. Cancers 2015, 7, 2262-2276.

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