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Cancers 2015, 7(4), 2201-2216; doi:10.3390/cancers7040886

Multiparametric Evaluation of Head and Neck Squamous Cell Carcinoma Using a Single-Source Dual-Energy CT with Fast kVp Switching: State of the Art

1
Department of Radiology, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada
2
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
3
Department of Radiology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
4
Lady Davis Research Institute, Montreal, QC H3T 1E2, Canada
5
Segal Cancer Centre, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Dirk Rades
Received: 1 September 2015 / Revised: 18 October 2015 / Accepted: 27 October 2015 / Published: 6 November 2015
View Full-Text   |   Download PDF [895 KB, uploaded 6 November 2015]   |  

Abstract

There is an increasing body of evidence establishing the advantages of dual-energy CT (DECT) for evaluation of head and neck squamous cell carcinoma (HNSCC). Focusing on a single-source DECT system with fast kVp switching, we will review the principles behind DECT and associated post-processing steps that make this technology especially suitable for HNSCC evaluation and staging. The article will review current applications of DECT for evaluation of HNSCC including use of different reconstructions to improve tumor conspicuity, tumor-normal soft tissue interface, accuracy of invasion of critical structures such as thyroid cartilage, and reduce dental artifact. We will provide a practical approach for DECT implementation into routine clinical use and a multi-parametric approach for scan interpretation based on the experience at our institution. The article will conclude with a brief overview of potential future applications of the technique. View Full-Text
Keywords: head and neck squamous cell carcinoma; dual energy CT; fast kVp switching; virtual monochromatic image; iodine overlay map; thyroid cartilage invasion; dental artifact reduction; lymphadenopathy head and neck squamous cell carcinoma; dual energy CT; fast kVp switching; virtual monochromatic image; iodine overlay map; thyroid cartilage invasion; dental artifact reduction; lymphadenopathy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lam, S.; Gupta, R.; Kelly, H.; Curtin, H.D.; Forghani, R. Multiparametric Evaluation of Head and Neck Squamous Cell Carcinoma Using a Single-Source Dual-Energy CT with Fast kVp Switching: State of the Art. Cancers 2015, 7, 2201-2216.

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