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Cancers 2015, 7(4), 2094-2109; doi:10.3390/cancers7040879

The Tip of the Iceberg: Clinical Implications of Genomic Sequencing Projects in Head and Neck Cancer

1
Department of Otolaryngology—Head and Neck Surgery, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
2
Comprehensive Cancer Center, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Maie A. St. John
Received: 29 August 2015 / Revised: 12 October 2015 / Accepted: 15 October 2015 / Published: 21 October 2015
(This article belongs to the Special Issue Head and Neck Cancer)
View Full-Text   |   Download PDF [921 KB, uploaded 21 October 2015]   |  

Abstract

Recent genomic sequencing studies have provided valuable insight into genetic aberrations in head and neck squamous cell carcinoma. Despite these great advances, certain hurdles exist in translating genomic findings to clinical care. Further correlation of genetic findings to clinical outcomes, additional analyses of subgroups of head and neck cancers and follow-up investigation into genetic heterogeneity are needed. While the development of targeted therapy trials is of key importance, numerous challenges exist in establishing and optimizing such programs. This review discusses potential upcoming steps for further genetic evaluation of head and neck cancers and implementation of genetic findings into precision medicine trials. View Full-Text
Keywords: HNSCC; targeted therapy; TCGA; genomic; cancer; precision medicine; personalized medicine HNSCC; targeted therapy; TCGA; genomic; cancer; precision medicine; personalized medicine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Birkeland, A.C.; Ludwig, M.L.; Meraj, T.S.; Brenner, J.C.; Prince, M.E. The Tip of the Iceberg: Clinical Implications of Genomic Sequencing Projects in Head and Neck Cancer. Cancers 2015, 7, 2094-2109.

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