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Cancers 2015, 7(4), 1983-1993; doi:10.3390/cancers7040871

Clinical Implications of Hedgehog Pathway Signaling in Prostate Cancer

Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans Street, CRB1-1M45, Baltimore, MD 21287, USA
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Author to whom correspondence should be addressed.
Academic Editor: Hui-Wen Lo
Received: 30 July 2015 / Revised: 11 September 2015 / Accepted: 22 September 2015 / Published: 29 September 2015
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Abstract

Activity in the Hedgehog pathway, which regulates GLI-mediated transcription, is important in organogenesis and stem cell regulation in self-renewing organs, but is pathologically elevated in many human malignancies. Mutations leading to constitutive activation of the pathway have been implicated in medulloblastoma and basal cell carcinoma, and inhibition of the pathway has demonstrated clinical responses leading to the approval of the Smoothened inhibitor, vismodegib, for the treatment of advanced basal cell carcinoma. Aberrant Hedgehog pathway signaling has also been noted in prostate cancer with evidence suggesting that it may render prostate epithelial cells tumorigenic, drive the epithelial-to-mesenchymal transition, and contribute towards the development of castration-resistance through autocrine and paracrine signaling within the tumor microenvironment and cross-talk with the androgen pathway. In addition, there are emerging clinical data suggesting that inhibition of the Hedgehog pathway may be effective in the treatment of recurrent and metastatic prostate cancer. Here we will review these data and highlight areas of active clinical research as they relate to Hedgehog pathway inhibition in prostate cancer. View Full-Text
Keywords: Hedgehog pathway; prostate cancer Hedgehog pathway; prostate cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Suzman, D.L.; Antonarakis, E.S. Clinical Implications of Hedgehog Pathway Signaling in Prostate Cancer. Cancers 2015, 7, 1983-1993.

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