Next Article in Journal
Histone Modifications, Modifiers and Readers in Melanoma Resistance to Targeted and Immune Therapy
Next Article in Special Issue
Next-Generation Sequencing in Clinical Molecular Diagnostics of Cancer: Advantages and Challenges
Previous Article in Journal
Therapy for BRAFi-Resistant Melanomas: Is WNT5A the Answer?
Previous Article in Special Issue
Analysis of Pre-Analytic Factors Affecting the Success of Clinical Next-Generation Sequencing of Solid Organ Malignancies
Article Menu

Export Article

Open AccessReview
Cancers 2015, 7(3), 1925-1958; doi:10.3390/cancers7030869

Next-Generation Sequencing Approaches in Cancer: Where Have They Brought Us and Where Will They Take Us?

1
Genome Science & Technology graduate program, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
2
Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada
3
Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Camile S. Farah and William Chi-shing Cho
Received: 8 July 2015 / Accepted: 15 September 2015 / Published: 23 September 2015
(This article belongs to the Special Issue Next Generation Sequencing Approaches in Cancer)
View Full-Text   |   Download PDF [223 KB, uploaded 23 September 2015]

Abstract

Next-generation sequencing (NGS) technologies and data have revolutionized cancer research and are increasingly being deployed to guide clinicians in treatment decision-making. NGS technologies have allowed us to take an “omics” approach to cancer in order to reveal genomic, transcriptomic, and epigenomic landscapes of individual malignancies. Integrative multi-platform analyses are increasingly used in large-scale projects that aim to fully characterize individual tumours as well as general cancer types and subtypes. In this review, we examine how NGS technologies in particular have contributed to “omics” approaches in cancer research, allowing for large-scale integrative analyses that consider hundreds of tumour samples. These types of studies have provided us with an unprecedented wealth of information, providing the background knowledge needed to make small-scale (including “N of 1”) studies informative and relevant. We also take a look at emerging opportunities provided by NGS and state-of-the-art third-generation sequencing technologies, particularly in the context of translational research. Cancer research and care are currently poised to experience significant progress catalyzed by accessible sequencing technologies that will benefit both clinical- and research-based efforts. View Full-Text
Keywords: cancer; next-generation sequencing; translational research; precision oncology medicine cancer; next-generation sequencing; translational research; precision oncology medicine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

LeBlanc, V.G.; Marra, M.A. Next-Generation Sequencing Approaches in Cancer: Where Have They Brought Us and Where Will They Take Us? Cancers 2015, 7, 1925-1958.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top