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Cancers 2015, 7(3), 1847-1862; doi:10.3390/cancers7030865

Exploration of Deregulated Long Non-Coding RNAs in Association with Hepatocarcinogenesis and Survival

1
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University Medical Center, New York, NY 10032, USA
2
Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York,NY 10032, USA
3
Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
4
Department of Pathology and Cell Biology, Columbia University Medical Center, New York,NY 10032, USA
Current address: University of Vermont College of Medicine, Box No. 374, 89 Beaumont Ave., Burlington, VT 05405, USA.
*
Author to whom correspondence should be addressed.
Academic Editor: Charles H. Lawrie
Received: 15 June 2015 / Revised: 1 September 2015 / Accepted: 2 September 2015 / Published: 10 September 2015
(This article belongs to the Special Issue Non-Coding RNAs in Cancers)
View Full-Text   |   Download PDF [414 KB, uploaded 10 September 2015]   |  

Abstract

Long non-coding RNAs (lncRNAs) are larger than 200 nucleotides in length and pervasively expressed across the genome. An increasing number of studies indicate that lncRNA transcripts play integral regulatory roles in cellular growth, division, differentiation and apoptosis. Deregulated lncRNAs have been observed in a variety of human cancers, including hepatocellular carcinoma (HCC). We determined the expression profiles of 90 lncRNAs for 65 paired HCC tumor and adjacent non-tumor tissues, and 55 lncRNAs were expressed in over 90% of samples. Eight lncRNAs were significantly down-regulated in HCC tumor compared to non-tumor tissues (p < 0.05), but no lncRNA achieved statistical significance after Bonferroni correction for multiple comparisons. Within tumor tissues, carrying more aberrant lncRNAs (6–7) was associated with a borderline significant reduction Cancers 2015, 7 1848 in survival (HR = 8.5, 95% CI: 1.0–72.5). The predictive accuracy depicted by the AUC was 0.93 for HCC survival when using seven deregulated lncRNAs (likelihood ratio test p = 0.001), which was similar to that combining the seven lncRNAs with tumor size and treatment (AUC = 0.96, sensitivity = 87%, specificity = 87%). These data suggest the potential association of deregulated lncRNAs with hepatocarcinogenesis and HCC survival. View Full-Text
Keywords: long non-coding RNAs; deregulation; HCC; HBV; survival long non-coding RNAs; deregulation; HCC; HBV; survival
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MDPI and ACS Style

Shen, J.; Siegel, A.B.; Remotti, H.; Wang, Q.; Shen, Y.; Santella, R.M. Exploration of Deregulated Long Non-Coding RNAs in Association with Hepatocarcinogenesis and Survival. Cancers 2015, 7, 1847-1862.

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