Next Article in Journal
The Role of Hedgehog Signaling in Tumor Induced Bone Disease
Next Article in Special Issue
MicroRNA Polymorphisms in Cancer: A Literature Analysis
Previous Article in Journal
Dichotomy in the Epigenetic Mark Lysine Acetylation is Critical for the Proliferation of Prostate Cancer Cells
Previous Article in Special Issue
Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis
Article Menu

Export Article

Open AccessReview
Cancers 2015, 7(3), 1643-1657; doi:10.3390/cancers7030855

MicroRNAs and Chinese Medicinal Herbs: New Possibilities in Cancer Therapy

1
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
2
Department of Anatomy, Li KaShing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
*
Author to whom correspondence should be addressed.
Academic Editor: Charles H. Lawrie
Received: 25 May 2015 / Revised: 4 August 2015 / Accepted: 17 August 2015 / Published: 24 August 2015
(This article belongs to the Special Issue Non-Coding RNAs in Cancers)
View Full-Text   |   Download PDF [129 KB, uploaded 24 August 2015]

Abstract

In recent decades Chinese medicine has been used worldwide as a complementary and alternative medicine to treat cancer. Plenty of studies have shown that microRNAs (miRNAs) play fundamental roles in many pathological processes, including cancer, while the anti-cancer mechanisms of Chinese medicinal herbs targeting miRNAs also have been extensively explored. Our previous studies and those of others on Chinese medicinal herbs and miRNAs in various cancer models have provided a possibility of new cancer therapies, for example, up-regulating the expression of miR-23a may activate the positive regulatory network of p53 and miR-23a involved in the mechanism underlying the anti-tumor effect of berberine in hepatocellular carcinoma (HCC). In this review, we survey the role of Chinese medicinal herbal products in regulating miRNAs in cancer and the use of mediating miRNAs for cancer treatment. In addition, the controversial roles of herb-derived exogenous miRNAs in cancer treatment are also discussed. It is expected that targeting miRNAs would provide a novel therapeutic approach in cancer therapy by improving overall response and survival outcomes in cancer treatment, especially when combined with conventional therapeutics and Chinese medicinal herbal products. View Full-Text
Keywords: microRNAs; Chinese medicinal herbs; cancer therapy; exogenous microRNAs microRNAs; Chinese medicinal herbs; cancer therapy; exogenous microRNAs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Hong, M.; Wang, N.; Tan, H.Y.; Tsao, S.-W.; Feng, Y. MicroRNAs and Chinese Medicinal Herbs: New Possibilities in Cancer Therapy. Cancers 2015, 7, 1643-1657.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top