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Cancers 2015, 7(3), 1406-1424; doi:10.3390/cancers7030843

Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis

Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
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Author to whom correspondence should be addressed.
Academic Editor: Charles H. Lawrie
Received: 12 June 2015 / Revised: 22 July 2015 / Accepted: 23 July 2015 / Published: 29 July 2015
(This article belongs to the Special Issue Non-Coding RNAs in Cancers)
View Full-Text   |   Download PDF [390 KB, uploaded 29 July 2015]   |  

Abstract

Long non-coding RNAs (LncRNAs) represent a novel class of RNAs with no functional protein-coding ability, yet it has become increasingly clear that interactions between lncRNAs with other molecules are responsible for important gene regulatory functions in various contexts. Given their relatively high expressions in the brain, lncRNAs are now thought to play important roles in normal brain development as well as diverse disease processes including gliomagenesis. Intriguingly, certain lncRNAs are closely associated with the initiation, differentiation, progression, recurrence and stem-like characteristics in glioma, and may therefore be exploited for the purposes of sub-classification, diagnosis and prognosis. LncRNAs may also serve as potential therapeutic targets as well as a novel biomarkers in the treatment of glioma. In this article, the functional aspects of lncRNAs, particularly within the central nervous system (CNS), will be briefly discussed, followed by highlights of the important roles of lncRNAs in mediating critical steps during glioma development. In addition, the key lncRNA players and their possible mechanistic pathways associated with gliomagenesis will be addressed. View Full-Text
Keywords: lncRNA; glioma; CRNDE; HOTAIR; H19; MEG3; glioblastoma stem cell; biomarker; gliomagenesis lncRNA; glioma; CRNDE; HOTAIR; H19; MEG3; glioblastoma stem cell; biomarker; gliomagenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kiang, K.M.-Y.; Zhang, X.-Q.; Leung, G.K.-K. Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis. Cancers 2015, 7, 1406-1424.

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