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Cancers 2015, 7(3), 1271-1291; doi:10.3390/cancers7030836

Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling

1,2,†,* and 1,2,†,*
1
Department of Life Sciences, Materials and Surface Science Institute and Stokes Institute, University of Limerick, Limerick 78666, Ireland
2
Health Research Institute (HRI), University of Limerick, Limerick 78666, Ireland
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Robert H. Weiss
Received: 27 March 2015 / Revised: 25 May 2015 / Accepted: 3 July 2015 / Published: 15 July 2015
(This article belongs to the Special Issue Cancer Cell Proliferation)
View Full-Text   |   Download PDF [894 KB, uploaded 15 July 2015]   |  

Abstract

The signaling outputs of Receptor Tyrosine Kinases, G-protein coupled receptors and integrins converge to mediate key cell process such as cell adhesion, cell migration, cell invasion and cell proliferation. Once activated by their ligands, these cell surface proteins recruit and direct a diverse range of proteins to disseminate the appropriate response downstream of the specific environmental cues. One of the key groups of proteins required to regulate these activities is the family of serine/threonine intracellular kinases called Protein Kinase Cs. The activity and subcellular location of PKCs are mediated by a series of tightly regulated events and is dependent on several posttranslational modifications and the availability of second messengers. Protein Kinase Cs exhibit both pro- and anti-tumorigenic effects making them an interesting target for anti-cancer treatment. View Full-Text
Keywords: growth factor signaling; receptor tyrosine kinase; G-protein coupled receptors; integrins; Protein Kinase C; cell proliferation; cell adhesion growth factor signaling; receptor tyrosine kinase; G-protein coupled receptors; integrins; Protein Kinase C; cell proliferation; cell adhesion
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Dowling, C.M.; Kiely, P.A. Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling. Cancers 2015, 7, 1271-1291.

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