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Cancers 2015, 7(3), 1178-1190; doi:10.3390/cancers7030831

Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions

1
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
2
Department of Radiation Oncology, University of Washington Medical Center, Seattle, WA 98195, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Xiaodong Zhang
Received: 31 March 2015 / Revised: 15 June 2015 / Accepted: 15 June 2015 / Published: 2 July 2015
(This article belongs to the Special Issue Proton Therapy for Cancer)
View Full-Text   |   Download PDF [622 KB, uploaded 2 July 2015]   |  

Abstract

Lung cancer is the leading cancer cause of death in the United States. Radiotherapy is an essential component of the definitive treatment of early-stage and locally-advanced lung cancer, and the palliative treatment of metastatic lung cancer. Proton beam therapy (PBT), through its characteristic Bragg peak, has the potential to decrease the toxicity of radiotherapy, and, subsequently improve the therapeutic ratio. Herein, we provide a primer on the physics of proton beam therapy for lung cancer, present the existing data in early-stage and locally-advanced non-small cell lung cancer (NSCLC), as well as in special situations such as re-irradiation and post-operative radiation therapy. We then present the technical challenges, such as anatomic changes and motion management, and future directions for PBT in lung cancer, including pencil beam scanning. View Full-Text
Keywords: lung cancer; radiotherapy; re-irradiation; proton beam therapy (PBT); post-operative radiation therapy (PORT) lung cancer; radiotherapy; re-irradiation; proton beam therapy (PBT); post-operative radiation therapy (PORT)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Berman, A.T.; James, S.S.; Rengan, R. Proton Beam Therapy for Non-Small Cell Lung Cancer: Current Clinical Evidence and Future Directions. Cancers 2015, 7, 1178-1190.

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