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Cancers 2015, 7(2), 849-875; doi:10.3390/cancers7020813

Voltage-Gated Ion Channels in Cancer Cell Proliferation

1
Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago 2160 S. 1s tAve, Maywood, IL 60153, USA
2
Department of Ophthalmology and Vision Research Center, School of Medicine, University of Missouri-Kansas City, 2411 Holmes St., Kansas City, MO 64108, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Vita Golubovskaya
Received: 30 March 2015 / Accepted: 12 May 2015 / Published: 22 May 2015
(This article belongs to the Special Issue Cancer Cell Proliferation)
View Full-Text   |   Download PDF [442 KB, uploaded 22 May 2015]   |  

Abstract

Changes of the electrical charges across the surface cell membrane are absolutely necessary to maintain cellular homeostasis in physiological as well as in pathological conditions. The opening of ion channels alter the charge distribution across the surface membrane as they allow the diffusion of ions such as K+, Ca++, Cl, Na+. Traditionally, voltage-gated ion channels (VGIC) are known to play fundamental roles in controlling rapid bioelectrical signaling including action potential and/or contraction. However, several investigations have revealed that these classes of proteins can also contribute significantly to cell mitotic biochemical signaling, cell cycle progression, as well as cell volume regulation. All these functions are critically important for cancer cell proliferation. Interestingly, a variety of distinct VGICs are expressed in different cancer cell types, including metastasis but not in the tissues from which these tumors were generated. Given the increasing evidence suggesting that VGIC play a major role in cancer cell biology, in this review we discuss the role of distinct VGIC in cancer cell proliferation and possible therapeutic potential of VIGC pharmacological manipulation. View Full-Text
Keywords: cancer; cell proliferation; voltage gated ion channel; membrane potential cancer; cell proliferation; voltage gated ion channel; membrane potential
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Rao, V.R.; Perez-Neut, M.; Kaja, S.; Gentile, S. Voltage-Gated Ion Channels in Cancer Cell Proliferation. Cancers 2015, 7, 849-875.

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