Cancers 2013, 5(4), 1242-1260; doi:10.3390/cancers5041242
Review

Vitamin D Is a Multilevel Repressor of Wnt/b-Catenin Signaling in Cancer Cells

email, email, email, email, email and * email
Received: 20 August 2013; in revised form: 2 October 2013 / Accepted: 10 October 2013 / Published: 21 October 2013
(This article belongs to the Special Issue Vitamin D: Role in Cancer Causation, Progression and Therapy)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The Wnt/b-catenin signaling pathway is abnormally activated in most colorectal cancers and in a proportion of other neoplasias. This activation initiates or contributes to carcinogenesis by regulating the expression of a large number of genes in tumor cells. The active vitamin D metabolite 1a,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits Wnt/b-catenin signaling by several mechanisms at different points along the pathway. Additionally, paracrine actions of 1,25(OH)2D3 on stromal cells may also repress this pathway in neighbouring tumor cells. Here we review the molecular basis for the various mechanisms by which 1,25(OH)2D3 antagonizes Wnt/b-catenin signaling, preferentially in human colon carcinoma cells, and the consequences of this inhibition for the phenotype and proliferation rate. The effect of the vitamin D system on Wnt/b-catenin signaling and tumor growth in animal models will also be commented in detail. Finally, we revise existing data on the relation between vitamin D receptor expression and vitamin D status and the expression of Wnt/b-catenin pathway genes and targets in cancer patients.
Keywords: vitamin D; 1a,25-dihydroxyvitamin D3; Wnt; b-catenin; colon cancer; vitamin D receptor
PDF Full-text Download PDF Full-Text [604 KB, uploaded 21 October 2013 13:53 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Larriba, M.J.; González-Sancho, J.M.; Barbáchano, A.; Niell, N.; Ferrer-Mayorga, G.; Muñoz, A. Vitamin D Is a Multilevel Repressor of Wnt/b-Catenin Signaling in Cancer Cells. Cancers 2013, 5, 1242-1260.

AMA Style

Larriba MJ, González-Sancho JM, Barbáchano A, Niell N, Ferrer-Mayorga G, Muñoz A. Vitamin D Is a Multilevel Repressor of Wnt/b-Catenin Signaling in Cancer Cells. Cancers. 2013; 5(4):1242-1260.

Chicago/Turabian Style

Larriba, María J.; González-Sancho, José M.; Barbáchano, Antonio; Niell, Núria; Ferrer-Mayorga, Gemma; Muñoz, Alberto. 2013. "Vitamin D Is a Multilevel Repressor of Wnt/b-Catenin Signaling in Cancer Cells." Cancers 5, no. 4: 1242-1260.

Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert