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Cancers 2013, 5(3), 1072-1085; doi:10.3390/cancers5031072
Review

Immune Regulatory Activity of Vitamin D3 in Head and Neck Cancer

1,2,3,*  and 2
Received: 24 May 2013; in revised form: 2 July 2013 / Accepted: 29 July 2013 / Published: 14 August 2013
(This article belongs to the Special Issue Vitamin D: Role in Cancer Causation, Progression and Therapy)
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Abstract: While vitamin D exhibits a multitude of cellular effects that can impact on cancer development and progression, this review focuses on its immune modulatory effects. These immune modulatory effects can be both direct and indirect. Compared to other cancer types, head and neck squamous cell carcinomas (HNSCC) have received less attention, but are a fascination immunologically because of the profound extent to which they inhibit immune defenses. This review describes the mechanisms of some of these immune inhibitory processes and how vitamin D can help overcome aspects of this immune suppression.
Keywords: head and neck cancer; HNSCC; immune modulation; immune suppression; suppressor cells; vitamin D head and neck cancer; HNSCC; immune modulation; immune suppression; suppressor cells; vitamin D
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Young, M.R.I.; Day, T.A. Immune Regulatory Activity of Vitamin D3 in Head and Neck Cancer. Cancers 2013, 5, 1072-1085.

AMA Style

Young MRI, Day TA. Immune Regulatory Activity of Vitamin D3 in Head and Neck Cancer. Cancers. 2013; 5(3):1072-1085.

Chicago/Turabian Style

Young, M. R.I.; Day, Terry A. 2013. "Immune Regulatory Activity of Vitamin D3 in Head and Neck Cancer." Cancers 5, no. 3: 1072-1085.



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