Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Cancers 2012, 4(1), 100-112; doi:10.3390/cancers4010100
Article

PET-Guided Surgery — High Correlation between Positron Emission Tomography with 11C-5-Hydroxytryptophane (5-HTP) and Surgical Findings in Abdominal Neuroendocrine Tumours

1
, 2,3
, 1
, 1
, 1
, 4
 and 4,*
Received: 29 November 2011; in revised form: 29 January 2012 / Accepted: 30 January 2012 / Published: 8 February 2012
(This article belongs to the Special Issue Neuroendocrine Tumors)
View Full-Text   |   Download PDF [211 KB, uploaded 8 February 2012]
Abstract: Positron emission tomography (PET) with 11C-labeled 5-hydroxytryptophane (5-HTP) is a sensitive technique to visualize neuroendocrine tumours (NETs), due to high intracellular uptake of amine-precursors like L-dihydroxyphenylalanine (L-DOPA) and 5-HTP. NETs are often small and difficult to localize in spite of overt clinical symptoms due to hormonal excess. In our study, 38 consecutive NET patients underwent 11C-5-HTP-PET and morphological imaging by CT within 12 weeks prior to surgery. Surgical, histopathological and 5-HTP PET findings were correlated. 11C-5-HTP-PET corresponded to the surgical findings in 31 cases, was false negative in six, and true negative in one case resulting in 83.8% sensitivity and 100% specificity. Positive predicted value was 100%. In 11 patients 11C-5-HTP-PET was the only imaging method applied to localize the tumour. Thus, we could demonstrate that functional imaging by 11C-5-HTP-PET in many cases adds vital preoperative diagnostic information and in more than every fourth patient was the only imaging method that will guide the surgeon in finding the NET-lesion. Although the present results demonstrates that 11C-5-HTP may be used as an universal NET tracer, the sensitivity to visualize benign insulinomas and non functioning pancreatic NETs was lower.
Keywords: neuroendocrine tumour; positron emission tomography; hydroxytryptophane; insulinoma; surgery neuroendocrine tumour; positron emission tomography; hydroxytryptophane; insulinoma; surgery
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Örlefors, H.; Sundin, A.; Eriksson, B.; Skogseid, B.; Öberg, K.; Åkerström, G.; Hellman, P. PET-Guided Surgery — High Correlation between Positron Emission Tomography with 11C-5-Hydroxytryptophane (5-HTP) and Surgical Findings in Abdominal Neuroendocrine Tumours. Cancers 2012, 4, 100-112.

AMA Style

Örlefors H, Sundin A, Eriksson B, Skogseid B, Öberg K, Åkerström G, Hellman P. PET-Guided Surgery — High Correlation between Positron Emission Tomography with 11C-5-Hydroxytryptophane (5-HTP) and Surgical Findings in Abdominal Neuroendocrine Tumours. Cancers. 2012; 4(1):100-112.

Chicago/Turabian Style

Örlefors, Håkan; Sundin, Anders; Eriksson, Barbro; Skogseid, Britt; Öberg, Kjell; Åkerström, Göran; Hellman, Per. 2012. "PET-Guided Surgery — High Correlation between Positron Emission Tomography with 11C-5-Hydroxytryptophane (5-HTP) and Surgical Findings in Abdominal Neuroendocrine Tumours." Cancers 4, no. 1: 100-112.



Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert