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TRAF4, at the Crossroad between Morphogenesis and Cancer
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), UMR 7104 CNRS, U964 INSERM, Université de Strasbourg, BP 10142, 67404 Illkirch, C.U. de Strasbourg, France
* Author to whom correspondence should be addressed.
Received: 12 May 2011; in revised form: 16 June 2011 / Accepted: 17 June 2011 / Published: 21 June 2011
Abstract: Tumor Necrosis Factor Receptor-Associated Factor 4 (TRAF4) is a gene whose expression is altered in cancers. It is overexpressed in a variety of carcinomas of different origins, often as a consequence of amplification. TRAF4 encodes an adaptor protein that belongs to the TRAF protein family. While most TRAF proteins influence immune and inflammation processes, TRAF4 is mainly involved in developmental and morphogenic processes. Interestingly, this protein has been shown to be linked to crucial cellular functions such as cell polarity and the regulation of reactive oxygen species production.
Keywords: TRAF; reactive oxygen species; cell polarity; morphogenesis; cancerogenesis; smurf
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MDPI and ACS Style
Rousseau, A.; Rio, M.-C.; Alpy, F. TRAF4, at the Crossroad between Morphogenesis and Cancer. Cancers 2011, 3, 2734-2749.
Rousseau A, Rio M-C, Alpy F. TRAF4, at the Crossroad between Morphogenesis and Cancer. Cancers. 2011; 3(2):2734-2749.
Rousseau, Adrien; Rio, Marie-Christine; Alpy, Fabien. 2011. "TRAF4, at the Crossroad between Morphogenesis and Cancer." Cancers 3, no. 2: 2734-2749.