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Cancers 2011, 3(2), 2141-2159; doi:10.3390/cancers3022141

Lymph Node Metastasis of Gastric Cancer

1,* , 2
1 Oita University Faculty of Medicine, Department of Gastroenterological Surgery, 1-1 Idaigaoka, Hasama-machi, Oita 879-5593, Japan 2 Surgical division, Center for community medicine, Oita University, 1- 1 Idaigaoka, Hasama-machi, Oita 879-5593, Japan
* Author to whom correspondence should be addressed.
Received: 9 February 2011 / Revised: 1 April 2011 / Accepted: 4 April 2011 / Published: 26 April 2011
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Despite a decrease in incidence in recent decades, gastric cancer is still one of the most common causes of cancer death worldwide [1]. In areas without screening for gastric cancer, it is diagnosed late and has a high frequency of nodal involvement [1]. Even in early gastric cancer (EGC), the incidence of lymph node (LN) metastasis exceeds 10%; it was reported to be 14.1% overall and was 4.8 to 23.6% depending on cancer depth [2]. It is important to evaluate LN status preoperatively for proper treatment strategy; however, sufficient results are not being obtained using various modalities. Surgery is the only effective intervention for cure or long-term survival. It is possible to cure local disease without distant metastasis by gastrectomy and LN dissection. However, there is no survival benefit from surgery for systemic disease with distant metastasis such as para-aortic lymph node metastasis [3]. Therefore, whether the disease is local or systemic is an important prognostic indicator for gastric cancer, and the debate continues over the importance of extended lymphadenectomy for gastric cancer. The concept of micro-metastasis has been described as a prognostic factor [4-9], and the biological mechanisms of LN metastasis are currently under study [10-12]. In this article, we review the status of LN metastasis including its molecular mechanisms and evaluate LN dissection for the treatment of gastric cancer.
Keywords: gastric cancer; lymph node metastasis; lymph node dissection gastric cancer; lymph node metastasis; lymph node dissection
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Akagi, T.; Shiraishi, N.; Kitano, S. Lymph Node Metastasis of Gastric Cancer. Cancers 2011, 3, 2141-2159.

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