Next Article in Journal
The Role of Tumour Stroma in Colorectal Cancer Invasion and Metastasis
Previous Article in Journal
Inferences for the Lead Time in Breast Cancer Screening Trials under a Stable Disease Model
Cancers 2011, 3(2), 2141-2159; doi:10.3390/cancers3022141
Review

Lymph Node Metastasis of Gastric Cancer

1,* , 2
 and 1
Received: 9 February 2011; in revised form: 1 April 2011 / Accepted: 4 April 2011 / Published: 26 April 2011
View Full-Text   |   Download PDF [250 KB, updated 27 April 2011; original version uploaded 26 April 2011]
Abstract: Despite a decrease in incidence in recent decades, gastric cancer is still one of the most common causes of cancer death worldwide [1]. In areas without screening for gastric cancer, it is diagnosed late and has a high frequency of nodal involvement [1]. Even in early gastric cancer (EGC), the incidence of lymph node (LN) metastasis exceeds 10%; it was reported to be 14.1% overall and was 4.8 to 23.6% depending on cancer depth [2]. It is important to evaluate LN status preoperatively for proper treatment strategy; however, sufficient results are not being obtained using various modalities. Surgery is the only effective intervention for cure or long-term survival. It is possible to cure local disease without distant metastasis by gastrectomy and LN dissection. However, there is no survival benefit from surgery for systemic disease with distant metastasis such as para-aortic lymph node metastasis [3]. Therefore, whether the disease is local or systemic is an important prognostic indicator for gastric cancer, and the debate continues over the importance of extended lymphadenectomy for gastric cancer. The concept of micro-metastasis has been described as a prognostic factor [4-9], and the biological mechanisms of LN metastasis are currently under study [10-12]. In this article, we review the status of LN metastasis including its molecular mechanisms and evaluate LN dissection for the treatment of gastric cancer.
Keywords: gastric cancer; lymph node metastasis; lymph node dissection gastric cancer; lymph node metastasis; lymph node dissection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Akagi, T.; Shiraishi, N.; Kitano, S. Lymph Node Metastasis of Gastric Cancer. Cancers 2011, 3, 2141-2159.

AMA Style

Akagi T, Shiraishi N, Kitano S. Lymph Node Metastasis of Gastric Cancer. Cancers. 2011; 3(2):2141-2159.

Chicago/Turabian Style

Akagi, Tomonori; Shiraishi, Norio; Kitano, Seigo. 2011. "Lymph Node Metastasis of Gastric Cancer." Cancers 3, no. 2: 2141-2159.


Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert