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Biomarkers for Basal-like Breast Cancer
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
* Author to whom correspondence should be addressed.
Received: 19 March 2010; in revised form: 11 May 2010 / Accepted: 19 May 2010 / Published: 28 May 2010
Abstract: Initially recognized through microarray-based gene expression profiling, basal-like breast cancer, for which we lack effective targeted therapies, is an aggressive form of carcinoma with a predilection for younger women. With some success, immunohistochemical studies have attempted to reproduce the expression profile classification of breast cancer through identification of subtype-specific biomarkers. This review aims to present an in depth summary and analysis of the current status of basal-like breast cancer biomarker research. While a number of biomarkers show promise for future clinical application, the next logical step is a comprehensive investigation of all biomarkers against a gene expression profile gold standard for breast cancer subtype assignment.
Keywords: breast cancer; basal-like; biomarkers; intrinsic subtype; immunohistochemistry; triple-negative; basaloid; expression profile
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MDPI and ACS Style
Choo, J.R.; Nielsen, T.O. Biomarkers for Basal-like Breast Cancer. Cancers 2010, 2, 1040-1065.
Choo JR, Nielsen TO. Biomarkers for Basal-like Breast Cancer. Cancers. 2010; 2(2):1040-1065.
Choo, Jennifer R.; Nielsen, Torsten O. 2010. "Biomarkers for Basal-like Breast Cancer." Cancers 2, no. 2: 1040-1065.