Cancers 2010, 2(2), 1040-1065; doi:10.3390/cancers2021040

Biomarkers for Basal-like Breast Cancer

email and * email
Received: 19 March 2010; in revised form: 11 May 2010 / Accepted: 19 May 2010 / Published: 28 May 2010
(This article belongs to the Special Issue Biomarkers: Oncology Studies)
View Full-Text   |   Download PDF [484 KB, uploaded 28 May 2010]
Abstract: Initially recognized through microarray-based gene expression profiling, basal-like breast cancer, for which we lack effective targeted therapies, is an aggressive form of carcinoma with a predilection for younger women. With some success, immunohistochemical studies have attempted to reproduce the expression profile classification of breast cancer through identification of subtype-specific biomarkers. This review aims to present an in depth summary and analysis of the current status of basal-like breast cancer biomarker research. While a number of biomarkers show promise for future clinical application, the next logical step is a comprehensive investigation of all biomarkers against a gene expression profile gold standard for breast cancer subtype assignment.
Keywords: breast cancer; basal-like; biomarkers; intrinsic subtype; immunohistochemistry; triple-negative; basaloid; expression profile
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |

MDPI and ACS Style

Choo, J.R.; Nielsen, T.O. Biomarkers for Basal-like Breast Cancer. Cancers 2010, 2, 1040-1065.

AMA Style

Choo JR, Nielsen TO. Biomarkers for Basal-like Breast Cancer. Cancers. 2010; 2(2):1040-1065.

Chicago/Turabian Style

Choo, Jennifer R.; Nielsen, Torsten O. 2010. "Biomarkers for Basal-like Breast Cancer." Cancers 2, no. 2: 1040-1065.

Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert