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Cancers 2010, 2(2), 1040-1065; doi:10.3390/cancers2021040
Review

Biomarkers for Basal-like Breast Cancer

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Received: 19 March 2010 / Revised: 11 May 2010 / Accepted: 19 May 2010 / Published: 28 May 2010
(This article belongs to the Special Issue Biomarkers: Oncology Studies)
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Abstract

Initially recognized through microarray-based gene expression profiling, basal-like breast cancer, for which we lack effective targeted therapies, is an aggressive form of carcinoma with a predilection for younger women. With some success, immunohistochemical studies have attempted to reproduce the expression profile classification of breast cancer through identification of subtype-specific biomarkers. This review aims to present an in depth summary and analysis of the current status of basal-like breast cancer biomarker research. While a number of biomarkers show promise for future clinical application, the next logical step is a comprehensive investigation of all biomarkers against a gene expression profile gold standard for breast cancer subtype assignment.
Keywords: breast cancer; basal-like; biomarkers; intrinsic subtype; immunohistochemistry; triple-negative; basaloid; expression profile breast cancer; basal-like; biomarkers; intrinsic subtype; immunohistochemistry; triple-negative; basaloid; expression profile
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Choo, J.R.; Nielsen, T.O. Biomarkers for Basal-like Breast Cancer. Cancers 2010, 2, 1040-1065.

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