Intraoperative Contrast-Enhanced Ultrasonography (Io-CEUS) in Minimally Invasive Thoracic Surgery for Characterization of Pulmonary Tumours: A Clinical Feasibility Study
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Study Hypothesis
2.3. Intraoperative Approach for Io-CEUS
3. Results
3.1. Study Population
3.2. Performance of Io-CEUS
3.3. Lung Carcinomas
3.4. Lung Metastases
3.5. Benign Nodule
3.6. Case 1
3.7. Case 2
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
Io-CEUS | intraoperative contrast-enhanced ultrasound |
CEUS | contrast-enhanced ultrasound |
SPN | solitary pulmonary nodule |
VATS | video-assisted thoracoscopy |
CCDS | colour-coded Doppler sonography |
PD | power Doppler |
CT | computed tomography |
TTP | time to peak |
SRI | spectral radiation imaging |
AUC | area under the curve |
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Total n = 30 (100%) | |
---|---|
Gender (female: n; %) | 14 (47%) |
Age (mean ± SD; years) | 64 ± 8.8 |
Side of surgery (n; %) | |
right | 15 (50) |
left | 15 (50) |
Localization of investigated suspicious SPNs (n; %) | |
upper lobe | 18 (60) |
middle lobe | 3 (10) |
lower lobe | 9 (30) |
Diameter in CT-scan of suspicious SPNs (mean ± SD) (cm) | 1.95 ± 1.1 |
Distance to lung surface (mean ± SD) (cm) | 2.02 ± 1.97 |
Total n = 30 (100%) | |
---|---|
Indication for surgery (n; %) | |
diagnostic | 21 (70) |
therapeutic | 9 (30) |
Frozen section (n; %) | n = 21 (70) |
primary lung carcinoma | 8 (38) |
metastasis | 8 (38) |
benign lesion | 3 (14) |
no frozen section | 2 (10) |
Lung resection (n; %) | |
enucleation | 1 (3) |
wedge resection | 9 (30) |
segmentectomy | 9 (30) |
lobectomy | 11 (37) |
Duration of surgery (mean ± SD; min) | 146 ± 58 |
Detection with Io-US (n; %) | 30 (100) |
Performance of Io-CEUS (n; %) | 30 (100) |
B-mode | 30 (100) |
Power Doppler | 30 (100) |
CEUS | 30 (100) |
Total n = 30 (100%) | |
---|---|
Lung carcinoma (n; %) | 16 (53) |
Adenocarcinoma | 10 (33) |
Typical carcinoid | 4 (13) |
Squamous cell carcinoma | 2 (7) |
Pulmonary metastasis (n; %) | 11 (37) |
Squamous cell carcinoma | 2 (7) |
Renal cell carcinoma | 1 (3) |
Cholangiocellular carcinoma | 1 (3) |
Sarcoma | 1 (3) |
Colon carcinoma | 1 (3) |
Lymphoma | 1 (3) |
Pancreatic carcinoma | 1 (3) |
Leiomyosarcoma | 1 (3) |
Liposarcoma | 1 (3) |
Malignant melanoma | 1 (3) |
Benign lesion (n; %) | 3 (10) |
Granuloma inflammatory | 1 (3) |
Granuloma rheumatoid | 1 (3) |
cryptogenic pneumonia | 1 (3) |
Tumour size (mean ± SD; cm) | 2.16 ± 1.12 |
Tumour size (mean ± SD; cm) | |
Lung carcinoma | 2.80 ± 1.03 |
Pulmonary metastasis | 1.76 ± 0.84 |
Benign lesion | 1.13 ± 0.32 |
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Schauer, M.I.; Jung, E.-M.; Platz Batista da Silva, N.; Akers, M.; Loch, E.; Markowiak, T.; Piler, T.; Larisch, C.; Neu, R.; Stroszczynski, C.; et al. Intraoperative Contrast-Enhanced Ultrasonography (Io-CEUS) in Minimally Invasive Thoracic Surgery for Characterization of Pulmonary Tumours: A Clinical Feasibility Study. Cancers 2023, 15, 3854. https://doi.org/10.3390/cancers15153854
Schauer MI, Jung E-M, Platz Batista da Silva N, Akers M, Loch E, Markowiak T, Piler T, Larisch C, Neu R, Stroszczynski C, et al. Intraoperative Contrast-Enhanced Ultrasonography (Io-CEUS) in Minimally Invasive Thoracic Surgery for Characterization of Pulmonary Tumours: A Clinical Feasibility Study. Cancers. 2023; 15(15):3854. https://doi.org/10.3390/cancers15153854
Chicago/Turabian StyleSchauer, Martin Ignaz, Ernst-Michael Jung, Natascha Platz Batista da Silva, Michael Akers, Elena Loch, Till Markowiak, Tomas Piler, Christopher Larisch, Reiner Neu, Christian Stroszczynski, and et al. 2023. "Intraoperative Contrast-Enhanced Ultrasonography (Io-CEUS) in Minimally Invasive Thoracic Surgery for Characterization of Pulmonary Tumours: A Clinical Feasibility Study" Cancers 15, no. 15: 3854. https://doi.org/10.3390/cancers15153854