The Role of Citrate Homeostasis in Merkel Cell Carcinoma Pathogenesis
Abstract
:Simple Summary
Abstract
1. Introduction
2. Results
2.1. Expression of PmCiC in Merkel Cell Carcinoma Cells and Merkel Cell Carcinoma Tissues
2.2. Proliferation of MCCs Is Increased in the Presence of Extracellular Citrate
2.3. Gluconate Inhibits Growth of Merkel Cell Carcinomas In Vivo
3. Discussion
4. Materials and Methods
4.1. Immunohistochemistry
4.2. Cell Culture
4.3. Chick Chorioallantoic Membrane Model
4.4. Statistics
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Drexler, K.; Schwertner, B.; Haerteis, S.; Aung, T.; Berneburg, M.; Geissler, E.K.; Mycielska, M.E.; Haferkamp, S. The Role of Citrate Homeostasis in Merkel Cell Carcinoma Pathogenesis. Cancers 2022, 14, 3425. https://doi.org/10.3390/cancers14143425
Drexler K, Schwertner B, Haerteis S, Aung T, Berneburg M, Geissler EK, Mycielska ME, Haferkamp S. The Role of Citrate Homeostasis in Merkel Cell Carcinoma Pathogenesis. Cancers. 2022; 14(14):3425. https://doi.org/10.3390/cancers14143425
Chicago/Turabian StyleDrexler, Konstantin, Barbara Schwertner, Silke Haerteis, Thiha Aung, Mark Berneburg, Edward K. Geissler, Maria E. Mycielska, and Sebastian Haferkamp. 2022. "The Role of Citrate Homeostasis in Merkel Cell Carcinoma Pathogenesis" Cancers 14, no. 14: 3425. https://doi.org/10.3390/cancers14143425