Correction: Liquori et al. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624
by
, , , and
Alessandro Liquori
1,†
,
Mariam Ibañez
2,3,†,
Claudia Sargas
1,
Miguel Ángel Sanz
2,3
,
Eva Barragán
2,3 and
José Cervera
2,3,* 1
Accredited Research Group in Hematology and Hemotherapy, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, Spain
2
Department of Hematology, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain
3
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
†
A.L. and M.I. contributed equally to this work.
Cancers 2021, 13(14), 3440; https://doi.org/10.3390/cancers13143440
Submission received: 12 May 2021
/
Accepted: 29 June 2021
/
Published: 9 July 2021
The authors wish to make the following corrections to this paper [1]:
In the last row of Table 2, translocation is t(3;17)(q26;q21) instead of t(1;17)(q42;q21).
In the last row of Table 2, ATO sensitivity should be changed to ND (not determined) instead of “Sensitive”.
The new Table 2 is shown below:
Table 2.
APL molecular variants.
| APL Molecular Variants | Translocations | ATRA Sensitivity | ATO Sensitivity | No. of Cases Reported | Gene Other Than PML, Breakpoint | Gene Other Than PML, Splice Site | Genomic Insertions | RARA, Breakpoint | RARA, Splice Site | Reference |
|---|---|---|---|---|---|---|---|---|---|---|
| ZBTB16 (PLZF)-RARA | t(11;17)(q23;q21) | Poorly responsive | Poorly responsive | >30 [85] | Intron 3 | CAGgtaggc | Intron 2 | ctctagCCA | [102] | |
| Intron 4 | CTGgtgagt | Intron 2 | ctctagCCA | [102] | ||||||
| NPM1-RARA | t(5;17)(q35;q21) | Sensitive | ND | 5 [103] | Intron 5 | CAGgtagag | Intron 2 | ctctagCCA | [103] | |
| Intron 5 | CAGgtagag | 79 nt with no homology to sequences in the GenBank or EMBL databases | Intron 2 | ctctagCCA | [104] | |||||
| Intron 4 | TAGgtatgt | Intron 2 | ctctagCCA | [103] | ||||||
| NUMA1 (NUMA)-RARA | t(11;17)(q13;q21) | Sensitive | ND | 1 | Intron 23 | CAGgtgagg | Intron 2 | ctctagCCA | [89] | |
| STAT5B-RARA | der(17) | Poorly responsive | Poorly responsive | 11 [105] | Intron 15 | CTCgtgagt | Intron 2 | ctctagCCA | [90,105] | |
| PRKAR1A-RARA | t(17;17)(q21;q24) or del(17)(q21;q24) | Sensitive | Sensitive | 1 | Intron 2 | AAGgtaaaa | Intron 2 | ctctagCCA | [91] | |
| FIP1L1-RARA | t(4;17)(q12;q21) | Sensitive in 1 case | ND | 2 | Intron 15 | ATGgtaagt | Intron 2 | ctctagCCA | [92] | |
| Intron 13 | CGGgtaaat | Intron 2 | ctctagCCA | [106] | ||||||
| BCOR-RARA | t(X;17)(p11;q21) | Sensitive in 2 cases | Insensitive in 1 case | 2 | Intron 12 | CAGgtatga | Intron 2 | ctctagCCA | [93] | |
| Exon 12 | CAGgtagaa | Intron 2 | ctctagCCA | [107] | ||||||
| NABP1 (OBFC2A)-RARA | t(2;17)(q32;q21) | Sensitive in vitro | ND | 1 | Intron 5 | TGGgtaaga | Intron 2 | ctctagCCA | [94] | |
| TBL1XR1 (TBLR1)-RARA | t(3;17)(q26;q21) | Insensitive | ND | 4 [108] | Intron 5 | CAAgtgagc | Intron 2 | ctctagCCA | [95] | |
| Intron 5 | CAAgtgagc | * | Intron 2 | ctctagCCA | [108] | |||||
| GTF2I-RARA | t(7;17)(q11;q21) | Sensitive | Sensitive | 1 | Intron 6 | TAGgtaagt | Intron 2 | ctctagCCA | [96] | |
| IRF2BP2-RARA | t(1;17)(q42;q21) | Sensitive | Sensitive | 5 [109] | Exon 2 | TGTcccctg | Intron 2 | ctctagCCA | [97,109] | |
| Exon 1 | AAGgtgcgg | Intron 2 | ctctagCCA | [110] | ||||||
| Intron 1 | CAGgtaggg | Intron 2 | ctctagCCA | [111] | ||||||
| Exon 1 | CAGgcaggt | Intron 2 | ctctagCCA | [111,112] | ||||||
| FNDC3B-RARA | t(3;17)(q26;q21) | Sensitive | ND | 1 | Intron 24 | AAGgtgtgt | Intron 2 | ctctagCCA | [98] |
The genes involved in APL molecular variants are reported according to the HUGO Gene Nomenclature Committee (https://www.genenames.org/, accessed on 8 March 2020). Previous symbols are reported in brackets. * According to molecular analysis, RARA on chromosome 17 had a 12-kbp deletion, of which a small region was inserted into chromosome X and the major part was inserted within the TBL1XR1 gene between exons 5 and 6 on chromosome 3 [108].
The authors would like to apologize for any inconvenience caused to the readers by these changes. The original manuscript has been updated.
Funding
This research received no external funding.
Conflicts of Interest
The authors declare no conflict of interest.
Reference
- Liquori, A.; Ibañez, M.; Sargas, C.; Sanz, M.Á.; Barragán, E.; Cervera, J. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624. [Google Scholar] [CrossRef] [PubMed] [Green Version]
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Liquori, A.; Ibañez, M.; Sargas, C.; Sanz, M.Á.; Barragán, E.; Cervera, J. Correction: Liquori et al. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624. Cancers 2021, 13, 3440. https://doi.org/10.3390/cancers13143440
AMA Style
Liquori A, Ibañez M, Sargas C, Sanz MÁ, Barragán E, Cervera J. Correction: Liquori et al. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624. Cancers. 2021; 13(14):3440. https://doi.org/10.3390/cancers13143440
Chicago/Turabian StyleLiquori, Alessandro, Mariam Ibañez, Claudia Sargas, Miguel Ángel Sanz, Eva Barragán, and José Cervera. 2021. "Correction: Liquori et al. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624" Cancers 13, no. 14: 3440. https://doi.org/10.3390/cancers13143440
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