Correction: Liquori et al. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624

Liquori, Alessandro; Ibañez, Mariam; Sargas, Claudia; Sanz, Miguel Ángel; Barragán, Eva; Cervera, José

doi:10.3390/cancers13143440

The authors wish to make the following corrections to this paper [1]:

In the last row of Table 2, translocation is t(3;17)(q26;q21) instead of t(1;17)(q42;q21).

In the last row of Table 2, ATO sensitivity should be changed to ND (not determined) instead of “Sensitive”.

The new Table 2 is shown below:

Table 2. APL molecular variants.

APL Molecular Variants	Translocations	ATRA Sensitivity	ATO Sensitivity	No. of Cases Reported	Gene Other Than PML, Breakpoint	Gene Other Than PML, Splice Site	Genomic Insertions	RARA, Breakpoint	RARA, Splice Site	Reference
ZBTB16 (PLZF)-RARA	t(11;17)(q23;q21)	Poorly responsive	Poorly responsive	>30 [85]	Intron 3	CAGgtaggc		Intron 2	ctctagCCA	[102]
ZBTB16 (PLZF)-RARA	t(11;17)(q23;q21)	Poorly responsive	Poorly responsive	>30 [85]	Intron 4	CTGgtgagt		Intron 2	ctctagCCA	[102]
NPM1-RARA	t(5;17)(q35;q21)	Sensitive	ND	5 [103]	Intron 5	CAGgtagag		Intron 2	ctctagCCA	[103]
					Intron 5	CAGgtagag	79 nt with no homology to sequences in the GenBank or EMBL databases	Intron 2	ctctagCCA	[104]
					Intron 4	TAGgtatgt		Intron 2	ctctagCCA	[103]
NUMA1 (NUMA)-RARA	t(11;17)(q13;q21)	Sensitive	ND	1	Intron 23	CAGgtgagg		Intron 2	ctctagCCA	[89]
STAT5B-RARA	der(17)	Poorly responsive	Poorly responsive	11 [105]	Intron 15	CTCgtgagt		Intron 2	ctctagCCA	[90,105]
PRKAR1A-RARA	t(17;17)(q21;q24) or del(17)(q21;q24)	Sensitive	Sensitive	1	Intron 2	AAGgtaaaa		Intron 2	ctctagCCA	[91]
FIP1L1-RARA	t(4;17)(q12;q21)	Sensitive in 1 case	ND	2	Intron 15	ATGgtaagt		Intron 2	ctctagCCA	[92]
FIP1L1-RARA	t(4;17)(q12;q21)	Sensitive in 1 case	ND	2	Intron 13	CGGgtaaat		Intron 2	ctctagCCA	[106]
BCOR-RARA	t(X;17)(p11;q21)	Sensitive in 2 cases	Insensitive in 1 case	2	Intron 12	CAGgtatga		Intron 2	ctctagCCA	[93]
BCOR-RARA	t(X;17)(p11;q21)	Sensitive in 2 cases	Insensitive in 1 case	2	Exon 12	CAGgtagaa		Intron 2	ctctagCCA	[107]
NABP1 (OBFC2A)-RARA	t(2;17)(q32;q21)	Sensitive in vitro	ND	1	Intron 5	TGGgtaaga		Intron 2	ctctagCCA	[94]
TBL1XR1 (TBLR1)-RARA	t(3;17)(q26;q21)	Insensitive	ND	4 [108]	Intron 5	CAAgtgagc		Intron 2	ctctagCCA	[95]
TBL1XR1 (TBLR1)-RARA	t(3;17)(q26;q21)	Insensitive	ND	4 [108]	Intron 5	CAAgtgagc	*	Intron 2	ctctagCCA	[108]
GTF2I-RARA	t(7;17)(q11;q21)	Sensitive	Sensitive	1	Intron 6	TAGgtaagt		Intron 2	ctctagCCA	[96]
IRF2BP2-RARA	t(1;17)(q42;q21)	Sensitive	Sensitive	5 [109]	Exon 2	TGTcccctg		Intron 2	ctctagCCA	[97,109]
					Exon 1	AAGgtgcgg		Intron 2	ctctagCCA	[110]
					Intron 1	CAGgtaggg		Intron 2	ctctagCCA	[111]
					Exon 1	CAGgcaggt		Intron 2	ctctagCCA	[111,112]
FNDC3B-RARA	t(3;17)(q26;q21)	Sensitive	ND	1	Intron 24	AAGgtgtgt		Intron 2	ctctagCCA	[98]

The genes involved in APL molecular variants are reported according to the HUGO Gene Nomenclature Committee (https://www.genenames.org/, accessed on 8 March 2020). Previous symbols are reported in brackets. * According to molecular analysis, RARA on chromosome 17 had a 12-kbp deletion, of which a small region was inserted into chromosome X and the major part was inserted within the TBL1XR1 gene between exons 5 and 6 on chromosome 3 [108].

The authors would like to apologize for any inconvenience caused to the readers by these changes. The original manuscript has been updated.

Funding

This research received no external funding.

Conflicts of Interest

The authors declare no conflict of interest.

Reference

Liquori, A.; Ibañez, M.; Sargas, C.; Sanz, M.Á.; Barragán, E.; Cervera, J. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624. [Google Scholar] [CrossRef] [Scilit] [PubMed]

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