Absence of Intraocular Lymphatic Vessels in Uveal Melanomas with Extrascleral Growth
Abstract
:1. Introduction
2. Results
2.1. Patients
2.2. Immunohistochemistry
3. Discussion
4. Materials and Methods
4.1. Sample Selection
4.2. Tissue Processing
4.3. Immunohistochemistry
4.4. Scoring of Immunohistochemistry
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Appendix A
References
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Patient Characteristics | Patients, n = 16 |
---|---|
Gender, No. (%) | |
Men | 7 (44) |
Women | 9 (56) |
Age in years, mean (SD) 1 | 66 (14) |
Tumor size classification | |
T1 | 3 |
T2 | 3 |
T3 | 7 |
T4 | 3 |
Largest diameter of the extension of the tumor in mm, mean (SD) 1 | 2.6 (2.5) |
Tumor location | |
Choroid | 9 |
Ciliary body | 7 |
Cell type | |
Epithelioid | 4 |
Mixed | 7 |
Spindle | 5 |
Disease-free survival in months, mean (SD) 1 | 77 (64) |
Alive, n | 9 |
Metastases, n | 4 |
Death, because of uveal melanoma, n | 3 |
Death other cause, n | 3 |
Lost to follow-up, n | 1 |
Markers | Expression of CD31 | Expression of D2-40 | Expression of LYVE-1 | Expression of Prox-1 | Expression of CD34 |
---|---|---|---|---|---|
Lymphatic vessel | + | + | + | + | − |
Sample 1 | + | − | − | − | + |
Sample 2 | + | − | − | − | + |
Sample 3 | + | − | − | − | + |
Sample 4 | + | − | − | − | + |
Sample 5 | + | − | − | − | + |
Sample 6 | + | − | − | − | + |
Sample 7 | + | − | − | − | + |
Sample 8 | + | − | + | − | + |
Sample 9 | + | − | − | − | + |
Sample 10 | + | − | − | − | + |
Sample 11 | + | − | − | − | + |
Sample 12 | + | − | − | − | + |
Sample 13 | + | − | − | − | + |
Sample 14 | + | − | − | − | + |
Sample 15 | + | − | + | − | + |
Sample 16 | + | − | − | − | + |
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van Beek, J.G.M.; van den Bosch, Q.C.C.; Naus, N.; Paridaens, D.; de Klein, A.; Kiliç, E.; Verdijk, R.M. Absence of Intraocular Lymphatic Vessels in Uveal Melanomas with Extrascleral Growth. Cancers 2019, 11, 228. https://doi.org/10.3390/cancers11020228
van Beek JGM, van den Bosch QCC, Naus N, Paridaens D, de Klein A, Kiliç E, Verdijk RM. Absence of Intraocular Lymphatic Vessels in Uveal Melanomas with Extrascleral Growth. Cancers. 2019; 11(2):228. https://doi.org/10.3390/cancers11020228
Chicago/Turabian Stylevan Beek, Jackelien G. M., Quincy C. C. van den Bosch, Nicole Naus, Dion Paridaens, Annelies de Klein, Emine Kiliç, and Robert M. Verdijk. 2019. "Absence of Intraocular Lymphatic Vessels in Uveal Melanomas with Extrascleral Growth" Cancers 11, no. 2: 228. https://doi.org/10.3390/cancers11020228