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RKIP: A Key Regulator in Tumor Metastasis Initiation and Resistance to Apoptosis: Therapeutic Targeting and Impact
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Cancers 2018, 10(9), 306; https://doi.org/10.3390/cancers10090306

Targeting Raf Kinase Inhibitory Protein Regulation and Function

1
Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA
2
Committee on Cancer Biology, University of Chicago, Chicago, IL 60637, USA
*
Author to whom correspondence should be addressed.
Received: 18 July 2018 / Revised: 24 August 2018 / Accepted: 30 August 2018 / Published: 4 September 2018
(This article belongs to the Special Issue Targeting Raf Kinase Inhibitor Protein (RKIP) in Cancer)
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Abstract

Raf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a non-metastatic state by rewiring kinase networks, elucidating the mechanism by which RKIP acts not only reveals molecular mechanisms that regulate metastasis, but also represents an opportunity to target these signaling networks therapeutically. Although RKIP is often lost during metastatic progression, the mechanism by which this occurs in tumor cells is complex and not well understood. In this review, we summarize our current understanding of RKIP regulation in tumors and consider experimental and computational strategies for recovering or mimicking its function by targeting mediators of metastasis. View Full-Text
Keywords: RKIP; metastasis; suppressor; kinase; therapy; signaling RKIP; metastasis; suppressor; kinase; therapy; signaling
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Yesilkanal, A.E.; Rosner, M.R. Targeting Raf Kinase Inhibitory Protein Regulation and Function. Cancers 2018, 10, 306.

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