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Toxins 2017, 9(6), 181; doi:10.3390/toxins9060181

Small and Smaller—sRNAs and MicroRNAs in the Regulation of Toxin Gene Expression in Prokaryotic Cells: A Mini-Review

1
Department of Molecular Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland
2
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Wita Stwosza 59, 80-308 Gdańsk, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Vernon L. Tesh
Received: 7 April 2017 / Revised: 9 May 2017 / Accepted: 26 May 2017 / Published: 30 May 2017
(This article belongs to the Section Bacterial Toxins)
View Full-Text   |   Download PDF [530 KB, uploaded 30 May 2017]   |  

Abstract

Non-coding small RNAs (sRNAs) have been identified in the wide range of bacteria (also pathogenic species) and found to play an important role in the regulation of many processes, including toxin gene expression. The best characterized prokaryotic sRNAs regulate gene expression by base pairing with mRNA targets and fall into two broad classes: cis-encoded sRNAs (also called antisense RNA) and trans-acting sRNAs. Molecules from the second class are frequently considered as the most related to eukaryotic microRNAs. Interestingly, typical microRNA-size RNA molecules have also been reported in prokaryotic cells, although they have received little attention up to now. In this work we have collected information about all three types of small prokaryotic RNAs in the context of the regulation of toxin gene expression. View Full-Text
Keywords: prokaryotes; non-coding small RNAs; microRNAs; toxin gene expression prokaryotes; non-coding small RNAs; microRNAs; toxin gene expression
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Bloch, S.; Węgrzyn, A.; Węgrzyn, G.; Nejman-Faleńczyk, B. Small and Smaller—sRNAs and MicroRNAs in the Regulation of Toxin Gene Expression in Prokaryotic Cells: A Mini-Review. Toxins 2017, 9, 181.

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