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Toxins 2017, 9(11), 370; doi:10.3390/toxins9110370

Evidence to Use Botulinum Toxin Injections in Tension-Type Headache Management: A Systematic Review

Department of Experimental Dentistry, Wroclaw Medical University, 50-425 Wroclaw, Poland
Department of Prosthetic Dentistry, Wroclaw Medical University, 50-425 Wroclaw, Poland
Department of Periodontology, Wroclaw Medical University, 50-425 Wroclaw, Poland
City Hospital No. 4, 44-100 Gliwice, Poland
Author to whom correspondence should be addressed.
Academic Editors: Jennifer G. Goldman and Codrin Lungu
Received: 23 September 2017 / Revised: 23 October 2017 / Accepted: 10 November 2017 / Published: 15 November 2017
(This article belongs to the Special Issue Muscle Selection for BoNT)
View Full-Text   |   Download PDF [454 KB, uploaded 15 November 2017]   |  


Tension-type headache (TTH) is the most common type of chronic recurring head pain. It can occur twice as often in women as in men. It is the most common type of headache. Its lifetime prevalence is 30% to 78% in the general population. TTH treatment should be multilevel. It often consists of taking pain medication, muscle relaxants, antidepressants, using biofeedback therapy, acupuncture, and attending behavioral therapy. Several clinical trials also suggest that botulinum toxin (BTX) may be an effective treatment option for such patients. The aim of this study was to evaluate if BTX can be used as a treatment method in TTH in the light of current medical literature. The authors searched the PubMed, EBSCOhost, OVID, Web of Knowledge, Cochrane Library and CINAHL databases to identify relevant publications. The authors finally included 11 papers—prospective and retrospective cohort studies. Among most of the selected studies, there was a significant correlation between using BTX and reduction of TTH pain intensity and severity. By analyzing qualified studies, it can be concluded that botulinum toxin seems to be effective in TTH management. View Full-Text
Keywords: tension type headache; botulinum toxin; injections tension type headache; botulinum toxin; injections

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wieckiewicz, M.; Grychowska, N.; Zietek, M.; Wieckiewicz, G.; Smardz, J. Evidence to Use Botulinum Toxin Injections in Tension-Type Headache Management: A Systematic Review. Toxins 2017, 9, 370.

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