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Toxins 2016, 8(5), 135; doi:10.3390/toxins8050135

Activity of Palythoa caribaeorum Venom on Voltage-Gated Ion Channels in Mammalian Superior Cervical Ganglion Neurons

1
Departamento de Química de Biomacromoléculas, Instituto de Química, Universidad Nacional Autónoma de México, Av. Universidad 3000, Ciudad Universitaria, Ciudad de México 04510, Mexico
2
Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Av. Universidad 3000, Ciudad Universitaria, Ciudad de México 04510, Mexico
3
Laboratorio de Biología de Cnidarios, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3250, Mar del Plata 7600, Argentina
*
Authors to whom correspondence should be addressed.
Academic Editors: Rong Chen and Yingliang Wu
Received: 10 March 2016 / Revised: 19 April 2016 / Accepted: 28 April 2016 / Published: 5 May 2016
(This article belongs to the Special Issue Animal Toxins and Biological Ion Channels)
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Abstract

The Zoanthids are an order of cnidarians whose venoms and toxins have been poorly studied. Palythoa caribaeorum is a zoanthid commonly found around the Mexican coastline. In this study, we tested the activity of P. caribaeorum venom on voltage-gated sodium channel (NaV1.7), voltage-gated calcium channel (CaV2.2), the A-type transient outward (IA) and delayed rectifier (IDR) currents of KV channels of the superior cervical ganglion (SCG) neurons of the rat. These results showed that the venom reversibly delays the inactivation process of voltage-gated sodium channels and inhibits voltage-gated calcium and potassium channels in this mammalian model. The compounds responsible for these effects seem to be low molecular weight peptides. Together, these results provide evidence for the potential use of zoanthids as a novel source of cnidarian toxins active on voltage-gated ion channels. View Full-Text
Keywords: cnidaria; zoanthids; Palythoa caribaeorum; voltage-gated ion channels; SCG neurons; MALDI-TOF-MS cnidaria; zoanthids; Palythoa caribaeorum; voltage-gated ion channels; SCG neurons; MALDI-TOF-MS
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MDPI and ACS Style

Lazcano-Pérez, F.; Castro, H.; Arenas, I.; García, D.E.; González-Muñoz, R.; Arreguín-Espinosa, R. Activity of Palythoa caribaeorum Venom on Voltage-Gated Ion Channels in Mammalian Superior Cervical Ganglion Neurons. Toxins 2016, 8, 135.

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