Next Article in Journal
Antivenom Cross-Neutralization of the Venoms of Hydrophis schistosus and Hydrophis curtus, Two Common Sea Snakes in Malaysian Waters
Next Article in Special Issue
Dual Effects Exerted in Vitro by Micromolar Concentrations of Deoxynivalenol on Undifferentiated Caco-2 Cells
Previous Article in Journal
Sulfasalazine Attenuates Staphylococcal Enterotoxin B-Induced Immune Responses
Article Menu

Export Article

Open AccessCommunication
Toxins 2015, 7(2), 560-571; doi:10.3390/toxins7020560

Chronic Exposure to Deoxynivalenol Has No Influence on the Oral Bioavailability of Fumonisin B1 in Broiler Chickens

1
Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium
2
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium
3
Biomin Research Center, Technopark 1, Tulln 3430, Austria
*
Author to whom correspondence should be addressed.
Academic Editor: Sven Dänicke
Received: 9 December 2014 / Revised: 15 January 2015 / Accepted: 9 February 2015 / Published: 16 February 2015
(This article belongs to the Collection Fusarium Toxins – Relevance for Human and Animal Health)
View Full-Text   |   Download PDF [321 KB, uploaded 16 February 2015]   |  

Abstract

Both deoxynivalenol (DON) and fumonisin B1 (FB1) are common contaminants of feed. Fumonisins (FBs) in general have a very limited oral bioavailability in healthy animals. Previous studies have demonstrated that chronic exposure to DON impairs the intestinal barrier function and integrity, by affecting the intestinal surface area and function of the tight junctions. This might influence the oral bioavailability of FB1, and possibly lead to altered toxicity of this mycotoxin. A toxicokinetic study was performed with two groups of 6 broiler chickens, which were all administered an oral bolus of 2.5 mg FBs/kg BW after three-week exposure to either uncontaminated feed (group 1) or feed contaminated with 3.12 mg DON/kg feed (group 2). No significant differences in toxicokinetic parameters of FB1 could be demonstrated between the groups. Also, no increased or decreased body exposure to FB1 was observed, since the relative oral bioavailability of FB1 after chronic DON exposure was 92.2%. View Full-Text
Keywords: Fusarium toxins; deoxynivalenol; fumonisin B1; broiler chickens; toxicokinetics; oral bioavailability Fusarium toxins; deoxynivalenol; fumonisin B1; broiler chickens; toxicokinetics; oral bioavailability
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Antonissen, G.; Devreese, M.; Van Immerseel, F.; De Baere, S.; Hessenberger, S.; Martel, A.; Croubels, S. Chronic Exposure to Deoxynivalenol Has No Influence on the Oral Bioavailability of Fumonisin B1 in Broiler Chickens. Toxins 2015, 7, 560-571.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top