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Toxins 2018, 10(5), 188; https://doi.org/10.3390/toxins10050188

Chronic Effects of Fusarium Mycotoxins in Rations with or without Increased Concentrate Proportion on the Insulin Sensitivity in Lactating Dairy Cows

1
Clinic for Cattle, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany
2
Institute of Animal Nutrition, Friedrich-Loeffler-Institute (FLI), Federal Research Institute for Animal Health, Bundesallee 37, 38116 Braunschweig, Germany
3
Clinic for Ruminants and Swine, Faculty of Veterinary Medicine, University Leipzig, An den Tierkliniken 11, 04103 Leipzig, Germany
4
Faculty of Veterinary Medicine, Justus-Liebig-University Giessen, Clinic for Veterinary Obstetrics, Gynecology and Andrology, Chair for Molecular Reproductive Medicine, Frankfurter Straße 106, 35392 Giessen, Germany
*
Author to whom correspondence should be addressed.
Received: 23 February 2018 / Revised: 24 March 2018 / Accepted: 2 May 2018 / Published: 8 May 2018
(This article belongs to the Collection Fusarium Toxins – Relevance for Human and Animal Health)
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Abstract

The objective of this study was to investigate the effect of long-term exposure to a Fusarium toxin deoxynivalenol (DON, 5 mg/kg DM) on the energy metabolism in lactating cows fed diets with different amounts of concentrate. In Period 1 27 German Holstein cows were assigned to two groups and fed a control or mycotoxin-contaminated diet with 50% concentrate for 11 weeks. In Period 2 each group was further divided and fed either a diet containing 30% or 60% concentrate for 16 weeks. Blood samples were collected in week 0, 4, 8, 15, 21, and 27 for calculation of the Revised Quantitative Insulin Sensitivity Check Index and biopsy samples of skeletal muscle and the liver in w 0, 15, and 27 for analysis by real-time RT-qPCR. The DON-fed groups presented lower insulin sensitivities than controls at week 27. Concomitantly, muscular mRNA expression of insulin receptors and hepatic mRNA expression of glucose transporter 2 and key enzymes for gluconeogenesis and fatty acid metabolism were lower in DON-fed cows compared to the control. The study revealed no consistent evidence that DON effects were modified by dietary concentrate levels. In conclusion, long-term dietary DON intake appears to have mild effects on energy metabolism in lactating dairy cows. View Full-Text
Keywords: deoxynivalenol; dairy cow; insulin sensitivity; energy metabolism deoxynivalenol; dairy cow; insulin sensitivity; energy metabolism
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Kinoshita, A.; Keese, C.; Meyer, U.; Starke, A.; Wrenzycki, C.; Dänicke, S.; Rehage, J. Chronic Effects of Fusarium Mycotoxins in Rations with or without Increased Concentrate Proportion on the Insulin Sensitivity in Lactating Dairy Cows. Toxins 2018, 10, 188.

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