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Nutrients 2017, 9(3), 281; doi:10.3390/nu9030281

Sensory Neuronopathy Revealing Severe Vitamin B12 Deficiency in a Patient with Anorexia Nervosa: An Often-Forgotten Reversible Cause

Hôpital de La Casamance, 13400 Aubagne, France
Service de Médecine Interne, Hôpital Européen, 13003 Marseille, France
Service de Neurologie, CHU Bordeaux 33000 Bordeaux, France
Author to whom correspondence should be addressed.
Received: 17 February 2017 / Revised: 9 March 2017 / Accepted: 13 March 2017 / Published: 15 March 2017
(This article belongs to the Special Issue Eating Disorders, Diet-Related Diseases, and Metabolic Health)
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Vitamin B12 (B12) deficiency is known to be associated with various neurological manifestations. Although central manifestations such as dementia or subacute combined degeneration are the most classic, neurological manifestations also include sensory neuropathies. However, B12 deficiency is still rarely integrated as a potential cause of sensory neuronopathy. Moreover, as many medical conditions can falsely normalize serum B12 levels even in the context of a real B12 deficiency, some cases may easily remain underdiagnosed. We report the illustrating case of an anorexic patient with sensory neuronopathy and consistently normal serum B12 levels. After all classical causes of sensory neuronopathy were ruled out, her clinical and electrophysiological conditions first worsened after folate administration, but finally improved dramatically after B12 administration. B12 deficiency should be systematically part of the etiologic workup of sensory neuronopathy, especially in a high risk context such as anorexia nervosa. View Full-Text
Keywords: sensory neuropathy; cobalamin deficiency; vitamin B12; anorexia nervosa sensory neuropathy; cobalamin deficiency; vitamin B12; anorexia nervosa
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Franques, J.; Chiche, L.; Mathis, S. Sensory Neuronopathy Revealing Severe Vitamin B12 Deficiency in a Patient with Anorexia Nervosa: An Often-Forgotten Reversible Cause. Nutrients 2017, 9, 281.

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