Next Article in Journal
The Impact of Shiftwork on Skeletal Muscle Health
Previous Article in Journal
Nutritional and Metabolic Derangements in Pancreatic Cancer and Pancreatic Resection
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Nutrients 2017, 9(3), 245; doi:10.3390/nu9030245

Polyunsaturated Fatty Acid Levels in Maternal  Erythrocytes of Japanese Women during Pregnancy  and after Childbirth

Faculty of Nutrition, Kagawa Nutrition University, 3‐9‐21 Chiyoda, Sakado, Saitama 350‐0288, Japan
Faculty of Comprehensive Human Sciences, Shokei Gakuin University, 4‐10‐1 Yurigaoka, Natori, Miyagi 981‐1295, Japan
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Sciences, Tohoku University, 468‐1 aza‐Aoba, Aramaki, Aoba‐ku, Sendai, Miyagi 980‐0845, Japan
New Industry Creation Hatchery Center (NICHe), Tohoku University, 6‐6‐10 aza‐Aoba, Aramaki, Aobaku, Sendai, Miyagi 980‐8579, Japan
Department of Gynecology and Obstetrics, Tohoku University Graduate School of Medicine, 2‐1 Seiryomachi, Aoba‐ku, Sendai, Miyagi 980‐8575, Japan
Department of Obstetrics and Gynecology, Yamagata Prefectural Central Hospital, 1800 Ooaza‐Aoyagi, Yamagata‐shi, Yamagata 990‐2292, Japan
Department of Informative Genetics, Tohoku University Graduate School of Medicine, 2‐1 Seiryo‐machi, Aoba‐ku, Sendai, Miyagi 980‐8575, Japan
Department of Development and Environmental Medicine, Tohoku University Graduate School of Medicine, 2‐1 Seiryo‐machi, Aoba‐ku, Sendai, Miyagi 980‐8575, Japan
Author to whom correspondence should be addressed.
Received: 12 January 2017 / Accepted: 3 March 2017 / Published: 7 March 2017
View Full-Text   |   Download PDF [516 KB, uploaded 9 March 2017]   |  


Background: The transport of polyunsaturated fatty acids (PUFAs), such as arachidonic acid (ARA, 20:4n‐6) and docosahexaenoic acid (DHA, 22:6n‐3), to the fetus from maternal stores increases depending on the fetal requirements for PUFA during the last trimester of pregnancy. Therefore, maternal blood PUFA changes physiologically with gestational age. However, the changes in PUFA levels in maternal blood erythrocytes during pregnancy and after childbirth have not been fully investigated in a fish‐eating population. Objective: To examine the changes of ARA and DHA levels in maternal erythrocytes with the progress of pregnancy and the relationship between maternal and umbilical cord erythrocyte PUFA levels in pregnant Japanese women who habitually eat fish and shellfish. Design: This study was performed as a part of the adjunct study of the Japan Environment and Children’s Study (JECS). The participants were 74 pregnant women. The maternal blood samples were collected at 27, 30, and 36 weeks of pregnancy, and 2 days and 1 month after delivery, and umbilical cord blood was collected at delivery. The fatty acid levels of erythrocytes in these blood samples were determined. Results: ARA and DHA levels in maternal erythrocytes tended to decrease with the progress of pregnancy. While the DHA level decreased further after delivery, the ARA level returned to the value at 27 weeks of pregnancy within 1 month after delivery. The n‐3 and n‐6 PUFA levels in maternal erythrocytes at 27, 30, and 36 weeks of pregnancy were significantly positively correlated with the corresponding fatty acid levels in umbilical cord erythrocytes. Conclusion: The present findings showed a significant change in erythrocyte PUFA levels during pregnancy and after childbirth in a fish‐eating population. The PUFA levels of maternal blood after the second trimester may be a reliable marker for predicting PUFA levels in infants’ circulating blood. View Full-Text
Keywords: pregnancy;  polyunsaturated  fatty  acid  (PUFA);  docosahexaenoic  acid  (DHA);  arachidonic acid (ARA); Japanese pregnancy;  polyunsaturated  fatty  acid  (PUFA);  docosahexaenoic  acid  (DHA);  arachidonic acid (ARA); Japanese

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kawabata, T.; Kagawa, Y.; Kimura, F.; Miyazawa, T.; Saito, S.; Arima, T.; Nakai, K.; Yaegashi, N. Polyunsaturated Fatty Acid Levels in Maternal  Erythrocytes of Japanese Women during Pregnancy  and after Childbirth. Nutrients 2017, 9, 245.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top