High Prevalence of Vitamin B12 Deficiency and No Folate Deficiency in Young Children in Nepal
AbstractMany children in low- and middle-income countries may have inadequate intake of vitamin B12 and folate; data confirming these inadequacies are limited. We used biochemical, demographic, behavioral and anthropometric data to describe the folate and vitamin B12 concentrations among six- to 23-month-old Nepalese children. Vitamin B12 (serum B12 < 150 pmol/L) and folate deficiencies (red blood cell (RBC) folate < 226.5 nmol/L) were assessed. We used logistic regression to identify predictors of vitamin B12 deficiency. The vitamin B12 geometric mean was 186 pmol/L; 30.2% of children were deficient. The mean RBC folate concentration was 13,612 nmol/L; there was no deficiency. Factors associated with vitamin B12 deficiency included: (a) age six to 11 months (adjusted odds ratio (aOR) 1.51; 95% confidence interval (CI): 1.18, 1.92) or 12–17 months (aOR 1.38; 95% CI: 1.10, 1.72) compared to 18–23 months; (b) being stunted (aOR 1.24; 95% CI: 1.03, 1.50) compared to not being stunted; (c) and not eating animal-source foods (aOR 1.85; 95% CI: 1.42, 2.41) compared to eating animal-source foods the previous day. There was a high prevalence of vitamin B12 deficiency, but no folate deficiency. Improving early feeding practices, including the consumption of rich sources of vitamin B12, such as animal-source foods and fortified foods, may help decrease deficiency. View Full-Text
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Ng’eno, B.N.; Perrine, C.G.; Whitehead, R.D.; Subedi, G.R.; Mebrahtu, S.; Dahal, P.; Jefferds, M.E.D. High Prevalence of Vitamin B12 Deficiency and No Folate Deficiency in Young Children in Nepal. Nutrients 2017, 9, 72.
Ng’eno BN, Perrine CG, Whitehead RD, Subedi GR, Mebrahtu S, Dahal P, Jefferds MED. High Prevalence of Vitamin B12 Deficiency and No Folate Deficiency in Young Children in Nepal. Nutrients. 2017; 9(1):72.Chicago/Turabian Style
Ng’eno, Bernadette N.; Perrine, Cria G.; Whitehead, Ralph D.; Subedi, Giri R.; Mebrahtu, Saba; Dahal, Pradiumna; Jefferds, Maria E.D. 2017. "High Prevalence of Vitamin B12 Deficiency and No Folate Deficiency in Young Children in Nepal." Nutrients 9, no. 1: 72.
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